Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K12 | Q12852 | 7/20 | 0.35 |
| ▸ | CDK1 | P06493 | 3/20 | 0.35 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.35 |
| ▸ | CDK2 | P24941 | 3/20 | 0.35 |
| ▸ | AHCY | P23526 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | DHFR | P00374 | 2/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.31 |
| ▸ | ALB | P02768 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.30 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.30 |
| ▸ | HRH2 | P25021 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28004983 | 0.82 | PKM (0.33) | MAP3K12 | |
| SCHEMBL27395069 | 0.78 | MAP3K12 (0.35) | MAP3K12CDK1CCNB1CCNE1CDK2 | |
| SCHEMBL27593680 | 0.76 | ADORA2A (0.40) | AHCYMAPK1HSD17B10ADORA2ACYP1A2 | |
| SCHEMBL6510998 | 0.74 | CDK1 (0.58) | CDK1CCNB1CCNE1CDK2AHCY | |
| SCHEMBL6268058 | 0.73 | HRH2 (0.38) | MAP3K12CDK1CCNB1CCNE1CDK2 | |
| SCHEMBL6270184 | 0.72 | HRH2 (0.40) | MAP3K12CDK1CCNB1CCNE1CDK2 | |
| SCHEMBL27531530 | 0.72 | CDK2 (0.39) | CDK1CCNB1CCNE1CDK2AHCY | |
| SCHEMBL17040218 | 0.72 | HSP90AB1 (0.47) | — | |
| SCHEMBL27220347 | 0.72 | CDK1 (0.42) | CDK1CCNB1CCNE1CDK2 | |
| SCHEMBL217726 | 0.71 | POLB (0.45) | CDK1CCNB1CCNE1CDK2ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104447746-A | Compound for activating AMPK and application thereof | HUAAN MEDICAL CO LTD | 2015-03-25 | — | — | CN | claimed |
| CN-104447746-A | Compound for activating AMPK and application thereof | HUAAN MEDICAL CO LTD | 2015-03-25 | — | — | CN | disclosed |
| US-8232275-B2 | 2,2-bis-(hydroxymethyl)cyclopropylidenemethyl-purines and -pyrimidines as antiviral agents | WAYNE STATE UNIVERSITY (US) | 2012-07-31 | — | — | US | disclosed |
| US-20110275652-A1 | 2,2-BIS-(HYDROXYMETHYL)CYCLOPROPYLIDENEMETHYL-PURINES AND -PYRIMIDINES AS ANTIVIRAL AGENTS | WAYNE STATE UNIVERSITY | 2011-11-10 | — | — | US | disclosed |
| EP-1490368-B1 | 2,2-BIS(HYDROXYMETHYL)CYCLOPROPYLIDENEMETHYL - PURINES AND -PYRIMIDINES AS ANTIVIRAL AGENTS | UNIV WAYNE STATE (US) | 2011-08-03 | — | — | EP | disclosed |
| CN-101429215-A | Process for selectively producing 1-phosphorylated sugar derivative anomer and process for producing nucleoside | MITSUI CHEMICALS INC (JP) | 2009-05-13 | — | — | CN | disclosed |
| US-20090118308-A1 | 2,2-Bis-(hydroxymethyl)cyclopropylidenemethyl-Purines and -Pyrimidines As Antiviral Agents | WAYNE STATE UNIVERSITY (US) | 2009-05-07 | — | — | US | disclosed |
| US-7393855-B2 | 2,2-bis-(hydroxymethyl)cyclopropylidenemethyl-purines and pyrimidines as antiviral agents | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2008-07-01 | — | — | US | disclosed |
| EP-1490368-A4 | 2,2-BIS(HYDROXYMETHYL)CYCLOPROPYLIDENEMETHYL - PURINES AND -PYRIMIDINES AS ANTIVIRAL AGENTS | UNIV WAYNE STATE (US) | 2006-07-19 | — | — | EP | disclosed |
| US-20050113393-A1 | 2,2-bis-(hydroxymethyl)cyclopropylidenemethyl-purines and pyrmindines as antiviral agents | WAYNE STATE UNIVERSITY (US) | 2005-05-26 | — | — | US | disclosed |
| EP-1490368-A2 | 2,2-BIS(HYDROXYMETHYL)CYCLOPROPYLIDENEMETHYL - PURINES AND -PYRIMIDINES AS ANTIVIRAL AGENTS | Wayne State University (US) | 2004-12-29 | — | — | EP | disclosed |
| WO-2003104440-A2 | 2,2-BIS(HYDROXYMETHYL)CYCLOPROPYLIDENEMETHYL - PURINES AND -PYRIMIDINES AS ANTIVIRAL AGENTS | WAYNE STATE UNIVERSITY (US) | 2003-12-18 | — | — | WO | disclosed |
| CN-1372564-A | Process for selectively preparing anomers of 1-phosphorylated sugar derivatives and process for preparing nucleosides | MITSUI CHEMICALS INC (JP) | 2002-10-02 | — | — | CN | disclosed |
| CN-1087089-A | The treatment nucleosides | WELLCOME FOUND (GB) | 1994-05-25 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110275652-A1 | 2,2-BIS-(HYDROXYMETHYL)CYCLOPROPYLIDENEMETHYL-PURINES AND -PYRIMIDINES AS ANTIVIRAL AGENTS | TPMT, HPRT1, MTAP | MAP3K12 4471/4885CDK1 3206/4885CCNB1 1662/4885 |
| US-20050113393-A1 | 2,2-bis-(hydroxymethyl)cyclopropylidenemethyl-purines and pyrmindines as antiviral agents | TPMT, HPRT1, MTAP | MAP3K12 4478/4885CDK1 3163/4885CCNB1 1783/4885 |
| US-20090118308-A1 | 2,2-Bis-(hydroxymethyl)cyclopropylidenemethyl-Purines and -Pyrimidines As Antiviral Agents | TPMT, HPRT1, MTAP | MAP3K12 4471/4885CDK1 3206/4885CCNB1 1662/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.