Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.33 |
| ▸ | MAPK13 | O15264 | 6/20 | 0.33 |
| ▸ | MAPK12 | P53778 | 6/20 | 0.33 |
| ▸ | MAPK11 | Q15759 | 5/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 2/20 | 0.32 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.32 |
| ▸ | TNF | P01375 | 1/20 | 0.32 |
| ▸ | LITAF | Q99732 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.32 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.32 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13376804 | 0.89 | CCNA2 (0.42) | TSHRPOLBMAPK14MAPK13MAPK12 | |
| SCHEMBL13380320 | 0.82 | MAPK13 (0.35) | TSHRPOLBMAPK14MAPK13MAPK12 | |
| SCHEMBL13376667 | 0.78 | MAPK13 (0.33) | TSHRPOLBMAPK14MAPK13MAPK12 | |
| SCHEMBL13376803 | 0.77 | CCNA2 (0.41) | MAPK14MAPK13MAPK12MAPK11KDM4E | |
| SCHEMBL13380326 | 0.70 | MAPK14 (0.36) | MAPK14MAPK13MAPK12MAPK11KDM4E | |
| SCHEMBL13376656 | 0.68 | MAPK14 (0.48) | MAPK14MAPK13MAPK12MAPK11CDK2 | |
| SCHEMBL13376802 | 0.66 | ALDH1A1 (0.43) | MAPK14MAPK13MAPK12MAPK11KDM4E | |
| SCHEMBL13376732 | 0.63 | MAPK14 (0.48) | MAPK14MAPK13MAPK12MAPK11CDK2 | |
| SCHEMBL12714295 | 0.62 | KDM4E (0.45) | TSHRMAPK14KDM4ECYP2C19NPSR1 | |
| SCHEMBL14969244 | 0.61 | NOTUM (0.46) | POLBKDM4EMAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7700771-B2 | Heterocyclic compound which may be used as a medicine having p38 MAP kinase inhibitory activity | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2010-04-20 | — | — | US | disclosed |
| US-20070185326-A1 | antiinflammatory agents; antiarthritic agents | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2007-08-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070185326-A1 | antiinflammatory agents; antiarthritic agents | MAPK1, CHUK, MAPK3 | TSHR 2801/4885POLB 4234/4885MAPK14 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.