Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 4/20 | 0.35 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.35 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 3/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13376804 | 0.84 | CCNA2 (0.42) | MAPK13MAPK12MAPK11MAPK14POLB | |
| SCHEMBL13376667 | 0.83 | MAPK13 (0.33) | MAPK13MAPK12MAPK11MAPK14POLB | |
| SCHEMBL13380339 | 0.82 | TSHR (0.35) | MAPK13MAPK12MAPK11MAPK14POLB | |
| SCHEMBL13376803 | 0.73 | CCNA2 (0.41) | MAPK13MAPK12MAPK11MAPK14SMN1; SMN2 | |
| SCHEMBL13376656 | 0.72 | MAPK14 (0.48) | MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL13376732 | 0.66 | MAPK14 (0.48) | MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL13380385 | 0.66 | MAPK14 (0.39) | MAPK13MAPK12MAPK11MAPK14KCNH2 | |
| SCHEMBL14969244 | 0.64 | NOTUM (0.46) | POLBSMN1; SMN2LMNANOTUM | |
| SCHEMBL1483873 | 0.62 | SMN1; SMN2 (0.41) | POLBSMN1; SMN2HKDC1NPC1CYP2C19 | |
| SCHEMBL13376802 | 0.61 | ALDH1A1 (0.43) | MAPK13MAPK12MAPK11MAPK14SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7700771-B2 | Heterocyclic compound which may be used as a medicine having p38 MAP kinase inhibitory activity | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2010-04-20 | — | — | US | disclosed |