Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 8/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.33 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.33 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.33 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | CASP7 | P55210 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.32 |
| ▸ | PRKDC | P78527 | 1/20 | 0.32 |
| ▸ | BTK | Q06187 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.31 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.31 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13376810 | 0.86 | MAPK14 (0.41) | MAPK14MAPK13MAPK12MAPK11AOC3 | |
| SCHEMBL13376669 | 0.85 | MAPK14 (0.36) | MAPK14MAPK13MAPK12MAPK11AOC3 | |
| SCHEMBL13380326 | 0.84 | MAPK14 (0.36) | MAPK14MAPK13MAPK12MAPK11AOC3 | |
| SCHEMBL13376635 | 0.81 | MAPK14 (0.47) | MAPK14MAPK13MAPK12MAPK11MAPK8 | |
| SCHEMBL13376808 | 0.72 | MAPK14 (0.42) | MAPK14MAPK13MAPK12MAPK11AOC3 | |
| SCHEMBL13376711 | 0.69 | MAPK14 (0.49) | MAPK14MAPK13MAPK12MAPK11AOC3 | |
| SCHEMBL13376636 | 0.66 | MAPK14 (0.47) | MAPK14MAPK13MAPK12MAPK11AOC3 | |
| SCHEMBL13380320 | 0.66 | MAPK13 (0.35) | MAPK14MAPK13MAPK12MAPK11KMT2A | |
| SCHEMBL13376809 | 0.62 | ALDH1A1 (0.43) | MAPK14MAPK13MAPK12MAPK11AOC3 | |
| SCHEMBL13376606 | 0.61 | MAPK14 (0.39) | MAPK14MAPK13MAPK12MAPK11AOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7700771-B2 | Heterocyclic compound which may be used as a medicine having p38 MAP kinase inhibitory activity | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2010-04-20 | — | — | US | disclosed |