SCHEMBL13385489

SCHEMBL13385489

Cc1cccc(-c2cc(Cl)c(-c3c(F)cccc3Cl)c(NC(C)C)n2)n1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NR4A2 P43354 2/20 0.38
CCR1 P32246 1/20 0.37
CCR8 P51685 1/20 0.37
NPC1 O15118 1/20 0.34
RAB9A P51151 1/20 0.34
PTGES O14684 1/20 0.33
MEN1 O00255 2/20 0.33
KMT2A Q03164 2/20 0.33
BTK Q06187 1/20 0.32
APLNR P35414 1/20 0.32
FGFR1 P11362 1/20 0.32
PDE2A O00408 1/20 0.32
PDE10A Q9Y233 1/20 0.32
MAP4K4 O95819 1/20 0.32
CCNT1 O60563 1/20 0.31
HCRTR1 O43613 1/20 0.31
HCRTR2 O43614 1/20 0.31
THRB P10828 1/20 0.31
TGFBR1 P36897 1/20 0.31
LMNA P02545 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13385481 0.85 CCR1 (0.43) CCR1CCR8NPC1MEN1KMT2A
SCHEMBL13385490 0.83 NR4A2 (0.43) NR4A2CCR1CCR8NPC1RAB9A
SCHEMBL13385407 0.81 CCR1 (0.44) CCR1CCR8NPC1RAB9APTGES
SCHEMBL3276721 0.78 BTK (0.34) NR4A2PTGESBTKFGFR1MAP4K4
SCHEMBL13385491 0.78 CYP1A1 (0.36) PTGESFGFR1
SCHEMBL13385495 0.77 RAB9A (0.40) NPC1RAB9APTGESMEN1KMT2A
SCHEMBL13385465 0.75 JAK2 (0.41) CCR1CCR8NPC1MEN1KMT2A
SCHEMBL3277906 0.75 MEN1 (0.45) CCR1CCR8NPC1RAB9AMEN1
SCHEMBL13385479 0.74 CCR1 (0.39) CCR1CCR8NPC1RAB9AMEN1
SCHEMBL13385470 0.73 SOS1 (0.41) CCR1CCR8MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7695728-B2 2-substituted pyridines, processes for their preparation and their use for controlling harmful fungi BASF AKTIENGESELLSCHAFT (DE) 2010-04-13 US disclosed
US-7695728-B2 2-substituted pyridines, processes for their preparation and their use for controlling harmful fungi BASF AKTIENGESELLSCHAFT (DE) 2010-04-13 US disclosed
US-20070259919-A1 2-Substituted Pyridines, Processes for their Preparation and Their Use for Controlling Harmful Fungi BASF AKIENGESELLSCHAFT (DE) 2007-11-08 US disclosed
US-20070259919-A1 2-Substituted Pyridines, Processes for their Preparation and Their Use for Controlling Harmful Fungi BASF AKIENGESELLSCHAFT (DE) 2007-11-08 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070259919-A1 2-Substituted Pyridines, Processes for their Preparation and Their Use for Controlling Harmful Fungi CYP4X1, CYCS, CYP2S1 NR4A2 779/4885CCR1 417/4885CCR8 2425/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.