Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.65 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14838804 | 0.83 | CYP1A2 (0.67) | CHRM5 | |
| SCHEMBL15649650 | 0.83 | GRM5 (0.63) | GRM5CHRM5 | |
| SCHEMBL13730442 | 0.83 | P4HTM (0.53) | GRM5 | |
| SCHEMBL13388104 | 0.82 | GRM5 (0.65) | GRM5 | |
| SCHEMBL13730987 | 0.82 | FFAR1 (0.55) | GRM5 | |
| SCHEMBL15650105 | 0.82 | GRM5 (0.64) | GRM5CHRM5 | |
| SCHEMBL13730336 | 0.82 | KMO (0.47) | GRM5CHRM5 | |
| SCHEMBL14838772 | 0.80 | CHRM5 (0.65) | CHRM5 | |
| SCHEMBL14838727 | 0.80 | GRM5 (0.66) | GRM5CHRM5 | |
| SCHEMBL14838741 | 0.80 | GRM5 (0.67) | GRM5CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2909178-B1 | ETHYNYL DERIVATIVES AS MODULATORS OF MGLUR5 RECEPTOR ACTIVITY | HOFFMANN LA ROCHE (CH) | 2016-10-05 | — | — | EP | disclosed |
| EP-2909178-B1 | ETHYNYL DERIVATIVES AS MODULATORS OF MGLUR5 RECEPTOR ACTIVITY | HOFFMANN LA ROCHE (CH) | 2016-10-05 | — | — | EP | disclosed |
| EP-2909180-B1 | ETHYNYL DERIVATIVES AS MODULATORS OF MGLUR5 RECEPTOR ACTIVITY | HOFFMANN LA ROCHE (CH) | 2016-10-05 | — | — | EP | disclosed |
| EP-2909180-B1 | ETHYNYL DERIVATIVES AS MODULATORS OF MGLUR5 RECEPTOR ACTIVITY | HOFFMANN LA ROCHE (CH) | 2016-10-05 | — | — | EP | disclosed |
| CN-104718192-B | ethynyl derivatives as modulators of MGLUR5 receptor activity | 霍夫曼-拉罗奇有限公司 | 2016-08-31 | — | — | CN | disclosed |
| CN-104603110-B | Ethynyl derivatives serving as the regulator of mGluR5 receptor active | 霍夫曼-拉罗奇有限公司 | 2016-08-31 | — | — | CN | disclosed |
| US-9359301-B2 | Ethynyl derivatives | HOFFMANN-LA ROCHE INC. (US) | 2016-06-07 | — | — | US | disclosed |
| US-9359301-B2 | Ethynyl derivatives | HOFFMANN-LA ROCHE INC. (US) | 2016-06-07 | — | — | US | disclosed |
| US-9359301-B2 | Ethynyl derivatives | HOFFMANN-LA ROCHE INC. (US) | 2016-06-07 | — | — | US | disclosed |
| US-9227959-B2 | Ethynyl derivatives | HOFFMAN-LA ROCHE INC. (US) | 2016-01-05 | — | — | US | disclosed |
| US-8772300-B2 | Phenyl or pyridinyl-ethynyl derivatives | HOFFMANN-LA ROCHE INC. (US) | 2014-07-08 | — | — | US | disclosed |
| US-8772300-B2 | Phenyl or pyridinyl-ethynyl derivatives | HOFFMANN-LA ROCHE INC. (US) | 2014-07-08 | — | — | US | disclosed |
| WO-2014060384-A1 | ETHYNYL DERIVATIVES AS MODULATORS OF MGLUR5 RECEPTOR ACTIVITY | F. HOFFMANN-LA ROCHE AG (CH) | 2014-04-24 | — | — | WO | disclosed |
| WO-2014060384-A1 | ETHYNYL DERIVATIVES AS MODULATORS OF MGLUR5 RECEPTOR ACTIVITY | F. HOFFMANN-LA ROCHE AG (CH) | 2014-04-24 | — | — | WO | disclosed |
| WO-2014060398-A1 | ETHYNYL DERIVATIVES AS MODULATORS OF MGLUR5 RECEPTOR ACTIVITY | F. HOFFMANN-LA ROCHE AG (CH) | 2014-04-24 | — | — | WO | disclosed |
| EP-2699547-A1 | 5-(PHENYL/PYRIDINYL-ETHINYL)-2-PYRIDINE/ 2-PYRIMIDINE-CARBORXAMIDES AS MGLUR5 MODULATORS | F. Hoffmann-La Roche AG (CH) | 2014-02-26 | — | — | EP | disclosed |
| WO-2013049255-A1 | SUBSTITUED 5-(PROP-1-YN-1-YL)PICOLINAMIDE ANALOGS AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS | VANDERBILT UNIVERSITY (US) | 2013-04-04 | — | — | WO | disclosed |
| WO-2012143340-A1 | 5-(PHENYL/PYRIDINYL-ETHINYL)-2-PYRIDINE/ 2-PYRIMIDINE-CARBORXAMIDES AS MGLUR5 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-10-26 | — | — | WO | disclosed |
| US-20120270852-A1 | PHENYL OR PYRIDINYL-ETHYNYL DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-10-25 | — | — | US | disclosed |
| US-20120270852-A1 | PHENYL OR PYRIDINYL-ETHYNYL DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-10-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120270852-A1 | PHENYL OR PYRIDINYL-ETHYNYL DERIVATIVES | GRM5, GRM1, GRM3 | GRM5 1/4885CHRM5 20/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.