Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 4/20 | 0.55 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.54 |
| ▸ | GRM5 | P41594 | 3/20 | 0.54 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.47 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13388104 | 0.82 | GRM5 (0.65) | GRM5 | |
| SCHEMBL13388628 | 0.82 | GRM5 (0.65) | GRM5 | |
| SCHEMBL22134783 | 0.78 | FFAR1 (0.56) | FFAR1SLC16A3FFAR4 | |
| SCHEMBL14838731 | 0.78 | CHRM5 (0.59) | EGLN1GRM5 | |
| SCHEMBL27950423 | 0.77 | FFAR1 (0.55) | FFAR1GRM5SLC16A3 | |
| SCHEMBL14838806 | 0.77 | — | — | |
| SCHEMBL8264172 | 0.76 | FFAR1 (0.61) | FFAR1EGLN1GRM5FFAR4 | |
| SCHEMBL16011593 | 0.76 | P4HTM (0.50) | EGLN1GRM5SLC16A3 | |
| SCHEMBL13730336 | 0.76 | KMO (0.47) | GRM5 | |
| SCHEMBL22134781 | 0.75 | SLC16A3 (0.49) | FFAR1EGLN1SLC16A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2699547-A1 | 5-(PHENYL/PYRIDINYL-ETHINYL)-2-PYRIDINE/ 2-PYRIMIDINE-CARBORXAMIDES AS MGLUR5 MODULATORS | F. Hoffmann-La Roche AG (CH) | 2014-02-26 | — | — | EP | disclosed |
| WO-2012143340-A1 | 5-(PHENYL/PYRIDINYL-ETHINYL)-2-PYRIDINE/ 2-PYRIMIDINE-CARBORXAMIDES AS MGLUR5 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-10-26 | — | — | WO | disclosed |