Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 12/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 12/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | CPT2 | P23786 | 1/20 | 0.32 |
| ▸ | CPT1A | P50416 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13391949 | 0.93 | ADORA1 (0.39) | ADORA1ADORA2APDE4DLRRK2 | |
| SCHEMBL13391834 | 0.88 | ADORA2A (0.39) | ADORA1ADORA2ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL13392063 | 0.87 | ADORA2A (0.40) | ADORA1ADORA2ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL13391902 | 0.86 | ADORA2A (0.39) | ADORA1ADORA2ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL13391929 | 0.85 | ADORA2A (0.40) | ADORA1ADORA2ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL13392016 | 0.83 | ADORA2A (0.37) | ADORA1ADORA2ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL13390601 | 0.83 | ADORA2A (0.47) | ADORA1ADORA2ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL13392015 | 0.83 | ADORA2A (0.42) | ADORA1ADORA2ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL13392083 | 0.83 | ADORA2A (0.40) | ADORA1ADORA2ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL13392032 | 0.83 | ADORA2A (0.41) | ADORA1ADORA2ACYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010045012-A1 | HETEROARYL AND PHENYL SUBSTITUTED THIENO [2,3-D] PYRIMIDINES AND THEIR USE AS ADENOSINE A2A RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2010-04-22 | — | — | WO | disclosed |
| US-20100093722-A1 | HETEROARYL AND PHENYL SUBSTITUTED THIENO[2,3-d]PYRIMIDINES AND THEIR USE AS ADENOSINE A2a RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2010-04-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100093722-A1 | HETEROARYL AND PHENYL SUBSTITUTED THIENO[2,3-d]PYRIMIDINES AND THEIR USE AS ADENOSINE A2a RECEPTOR ANTAGONISTS | ADORA2A, ADORA3, ADORA2B | ADORA1 4/4885ADORA2A 1/4885CYP1A2 955/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.