Sugi Predict

Sugi Predict / Compounds / SCHEMBL1339490

SCHEMBL1339490

SCHEMBL1339490

CCC(=O)c1ccc2c(c1)c1cc(-c3ccc(F)cc3)c(=O)n(C)c1n2C

nearest known ligand 0.40

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ CHRNA7 P36544 3/20 0.40
▸ KMT2A Q03164 3/20 0.37
▸ MEN1 O00255 2/20 0.37
▸ KCNH2 Q12809 1/20 0.37
▸ NPC1 O15118 2/20 0.37
▸ RAB9A P51151 1/20 0.37
▸ SIGMAR1 Q99720 2/20 0.36
▸ GAA P10253 1/20 0.35
▸ MAPT P10636 3/20 0.35
▸ ALDH1A1 P00352 2/20 0.35
▸ TSHR P16473 2/20 0.35
▸ PIK3CA P42336 1/20 0.35
▸ MAPK1 P28482 1/20 0.35
▸ SMN1; SMN2 Q16637 1/20 0.35
▸ HSD17B10 Q99714 1/20 0.35
▸ PARG Q86W56 1/20 0.35
▸ KDM4E B2RXH2 1/20 0.34
▸ PGR P06401 1/20 0.34
▸ HPGD P15428 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1336822 0.90 PTPN1 (0.43) CHRNA7KMT2AMEN1NPC1RAB9A
SCHEMBL1337044 0.89 CXCR3 (0.39) CHRNA7KCNH2SIGMAR1MAPTSMN1; SMN2
SCHEMBL1339208 0.87 KDM4E (0.42) KMT2AMEN1MAPTALDH1A1PIK3CA
SCHEMBL1338594 0.85 ASAH1 (0.34) CHRNA7KMT2ANPC1RAB9AGAA
SCHEMBL1339122 0.83 MAPK14 (0.35) NPC1MAPTALDH1A1PIK3CASMN1; SMN2
SCHEMBL4790860 0.81 CHRNA7 (0.40) CHRNA7KMT2AMEN1KCNH2SIGMAR1
SCHEMBL1338600 0.80 KMT2A (0.49) KMT2AMEN1NPC1RAB9AGAA
SCHEMBL1338598 0.80 KMT2A (0.49) KMT2AMEN1NPC1RAB9AGAA
SCHEMBL1338964 0.80 GSK3B (0.41) KMT2AMEN1NPC1GAAKDM4E
SCHEMBL1339045 0.79 MAPT (0.33) KMT2AMEN1MAPTPIK3CAKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8063061-B2 6-(2-amino-1,3-thiazol-4-yl)-3-(2,4-dichlorophenyl)-1-methyl-1,9-dihydro-2H-pyrido[2,3-b]indol-2-one; affinity for GABAA-receptor-associated omega modulatory sites SANOFI-AVENTIS (FR) 2011-11-22 — — US disclosed
EP-1940840-B1 6-HETEROARYLPYRIDOINDOLONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF SANOFI AVENTIS (FR) 2010-07-21 — — EP disclosed
US-20080262020-A1 6-Heteroarylpyridoindolone Derivatives, Their Preparation and Therapeutic Use Thereof SANOFI-AVENTIS (FR) 2008-10-23 — — US disclosed
EP-1940840-A1 6-HETEROARYLPYRIDOINDOLONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF Sanofi-Aventis (FR) 2008-07-09 — — EP disclosed
WO-2007045758-A1 6-HETEROARYLPYRIDOINDOLONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF SANOFI AVENTIS (FR) 2007-04-26 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080262020-A1 6-Heteroarylpyridoindolone Derivatives, Their Preparation and Therapeutic Use Thereof CYP11B2, CYP11B1, CYP2D6 CHRNA7 1754/4885KMT2A 2956/4885MEN1 2522/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.