Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ULK1 | O75385 | 1/20 | 0.63 |
| ▸ | ALK | Q9UM73 | 6/20 | 0.59 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.56 |
| ▸ | EGFR | P00533 | 3/20 | 0.55 |
| ▸ | IGF1R | P08069 | 3/20 | 0.55 |
| ▸ | PLK4 | O00444 | 2/20 | 0.55 |
| ▸ | LCK | P06239 | 2/20 | 0.55 |
| ▸ | FYN | P06241 | 2/20 | 0.55 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.55 |
| ▸ | FLT3 | P36888 | 2/20 | 0.55 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.55 |
| ▸ | PTK6 | Q13882 | 2/20 | 0.55 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.55 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.55 |
| ▸ | SLK | Q9H2G2 | 2/20 | 0.55 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.55 |
| ▸ | INSR | P06213 | 2/20 | 0.55 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.55 |
| ▸ | GAK | O14976 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14866368 | 0.89 | ALK (0.75) | ULK1ALKPTK2EGFRIGF1R | |
| SCHEMBL13395660 | 0.87 | ALK (0.56) | ULK1ALKPTK2EGFRIGF1R | |
| SCHEMBL2822748 | 0.81 | ALK (0.81) | ULK1ALKPTK2EGFRIGF1R | |
| SCHEMBL12892783 | 0.79 | ULK1 (0.73) | ULK1ALKPTK2EGFRIGF1R | |
| SCHEMBL14866619 | 0.78 | ALK (0.70) | ULK1ALKPTK2EGFRIGF1R | |
| SCHEMBL12780145 | 0.78 | ZAP70 (0.85) | ULK1ALKPTK2EGFRIGF1R | |
| SCHEMBL29900883 | 0.77 | ULK1 (1.00) | ULK1ALKPTK2EGFRIGF1R | |
| SCHEMBL375608 | 0.77 | ULK1 (1.00) | ULK1ALKPTK2EGFRIGF1R | |
| SCHEMBL12892894 | 0.77 | ULK1 (0.83) | ULK1ALKPTK2EGFRIGF1R | |
| SCHEMBL2824078 | 0.77 | ALK (0.75) | ULK1ALKPTK2EGFRIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130096100-A1 | DI(ARYLAMINO)ARYL COMPOUND | ASTELLAS PHARMA INC. (JP) | 2013-04-18 | — | — | US | disclosed |
| US-8318702-B2 | Di(arylamino)aryl compounds | ASTELLAS PHARMA INC. (JP) | 2012-11-27 | — | — | US | disclosed |
| US-8318702-B2 | Di(arylamino)aryl compounds | ASTELLAS PHARMA INC. (JP) | 2012-11-27 | — | — | US | disclosed |
| US-20100099658-A1 | DI(ARYLAMINO)ARYL COMPOUND | ASTELLAS PHARMA INC. (JP) | 2010-04-22 | — | — | US | disclosed |
| US-20100099658-A1 | DI(ARYLAMINO)ARYL COMPOUND | ASTELLAS PHARMA INC. (JP) | 2010-04-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130096100-A1 | DI(ARYLAMINO)ARYL COMPOUND | ERBB4, EGFR, ALK | ULK1 3381/4885ALK 3/4885PTK2 375/4885 |
| US-20100099658-A1 | DI(ARYLAMINO)ARYL COMPOUND | ERBB4, EGFR, ALK | ULK1 3381/4885ALK 3/4885PTK2 375/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.