Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ULK1 | O75385 | 4/20 | 1.00 |
| ▸ | ZAP70 | P43403 | 6/20 | 0.71 |
| ▸ | ALK | Q9UM73 | 6/20 | 0.70 |
| ▸ | EGFR | P00533 | 4/20 | 0.70 |
| ▸ | IGF1R | P08069 | 3/20 | 0.70 |
| ▸ | GSK3A | P49840 | 2/20 | 0.70 |
| ▸ | CDC7 | O00311 | 2/20 | 0.70 |
| ▸ | PLK4 | O00444 | 2/20 | 0.70 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.70 |
| ▸ | AURKA | O14965 | 2/20 | 0.70 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.70 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.70 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.70 |
| ▸ | JAK2 | O60674 | 2/20 | 0.70 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.70 |
| ▸ | PAK4 | O96013 | 2/20 | 0.70 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.70 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.70 |
| ▸ | PRKCG | P05129 | 2/20 | 0.70 |
| ▸ | LCK | P06239 | 2/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL375608 | 1.00 | ULK1 (1.00) | ULK1ZAP70ALKEGFRIGF1R | |
| SCHEMBL380944 | 0.94 | ULK1 (0.88) | ULK1ZAP70ALKEGFRIGF1R | |
| SCHEMBL12781486 | 0.92 | ULK1 (0.85) | ULK1ZAP70ALKEGFRIGF1R | |
| SCHEMBL12892788 | 0.92 | ULK1 (0.84) | ULK1ZAP70ALKEGFRIGF1R | |
| SCHEMBL12780549 | 0.92 | ULK1 (0.84) | ULK1ZAP70ALKEGFRIGF1R | |
| SCHEMBL282266 | 0.91 | ULK1 (0.84) | ULK1ZAP70ALKEGFRIGF1R | |
| SCHEMBL12780145 | 0.91 | ZAP70 (0.85) | ULK1ZAP70ALKEGFRIGF1R | |
| SCHEMBL12892784 | 0.91 | ULK1 (0.83) | ULK1ZAP70ALKEGFRIGF1R | |
| SCHEMBL375362 | 0.91 | ULK1 (0.83) | ULK1ZAP70ALKEGFRIGF1R | |
| SCHEMBL12892894 | 0.91 | ULK1 (0.83) | ULK1ZAP70ALKEGFRIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4070795-A1 | NOVEL ULK1 INHIBITORS AND METHODS USING SAME | Salk Institute for Biological Studies (US) | 2022-10-12 | — | — | EP | disclosed |