SCHEMBL13402005

SCHEMBL13402005

Cc1ccc(C=CC2CCC(COc3ccc(C)cc3)CC2)cc1

nearest known ligand 0.47

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
MAOB P27338 4/20 0.47
APP P05067 1/20 0.44
HPGD P15428 4/20 0.42
RELA Q04206 1/20 0.41
PARP15 Q460N3 1/20 0.41
PARP10 Q53GL7 1/20 0.41
PARP2 Q9UGN5 1/20 0.41
TDP1 Q9NUW8 1/20 0.40
KDM1A O60341 1/20 0.40
CHRNB2 P17787 2/20 0.39
CHRNB4 P30926 2/20 0.39
CHRNA3 P32297 2/20 0.39
CHRNA7 P36544 2/20 0.39
CHRNA4 P43681 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8930160 0.82 PARP15 (0.55) PARP15PARP10PARP2TDP1KDM1A
SCHEMBL2665020 0.82 PARP15 (0.55) PARP15PARP10PARP2TDP1KDM1A
SCHEMBL10311493 0.82 MAOB (0.34) MAOBAPPHPGDKDM1A
SCHEMBL13402019 0.82 MAOB (0.44) MAOBPARP15PARP10PARP2
Ammonia Solution, Strong SCHEMBL28413630 0.81 PARP15 (0.53) PARP15PARP10PARP2TDP1KDM1A
SCHEMBL30105 0.80 PARP15 (0.44) HPGDPARP15PARP10PARP2TDP1
SCHEMBL14329775 0.80 RELA (0.67) MAOBHPGDRELA
SCHEMBL5778181 0.76 HPGD (0.50) MAOBHPGDPARP15PARP10PARP2
SCHEMBL14451132 0.76 HPGD (0.52) HPGDPARP15PARP10PARP2TDP1
SCHEMBL11164865 0.76 PARP15 (0.57) HPGDPARP15PARP10PARP2TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8420764-B2 Compound having silsesquioxane skeleton and its polymer JNC CORPORATION (JP) 2013-04-16 US disclosed
US-7705105-B2 A cyclic polymer of silsesquioxane skeleton with side chains formed byhydrosilation of an unsaturated end group containing an active polymerfunctional group; polyimidesiloxane copolymers; polyestersiloxane copolymers; high molecular weight; thin films; strength; heat resistance;waterproofing; CHISSO PETROCHEMICAL CORPORATION (JP) 2010-04-27 US disclosed
US-20070190344-A1 Verification of translation JNC CORPORATION (JP) 2007-08-16 US disclosed