Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 10/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 6/20 | 0.58 |
| ▸ | TSHR | P16473 | 3/20 | 0.58 |
| ▸ | USP2 | O75604 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.57 |
| ▸ | RAB9A | P51151 | 3/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.54 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13401521 | 0.91 | HPGD (0.67) | HPGDKMT2AALDH1A1MEN1SMN1; SMN2 | |
| SCHEMBL24163547 | 0.88 | HPGD (0.65) | HPGDKMT2AALDH1A1MEN1SMN1; SMN2 | |
| SCHEMBL24163544 | 0.86 | HPGD (0.79) | HPGDKMT2AALDH1A1MEN1SMN1; SMN2 | |
| SCHEMBL3456248 | 0.85 | HPGD (0.77) | HPGDKMT2AALDH1A1MEN1SMN1; SMN2 | |
| SCHEMBL3281854 | 0.82 | HPGD (0.67) | HPGDKMT2AALDH1A1MEN1SMN1; SMN2 | |
| SCHEMBL3276219 | 0.82 | HPGD (0.63) | HPGDKMT2AALDH1A1MEN1SMN1; SMN2 | |
| SCHEMBL2829098 | 0.80 | HPGD (0.67) | HPGDKMT2AALDH1A1MEN1SMN1; SMN2 | |
| SCHEMBL4378295 | 0.80 | HPGD (0.70) | HPGDKMT2AALDH1A1MEN1SMN1; SMN2 | |
| SCHEMBL4381856 | 0.79 | HPGD (0.69) | HPGDKMT2AALDH1A1MEN1SMN1; SMN2 | |
| SCHEMBL24163542 | 0.78 | HPGD (1.00) | HPGDKMT2AALDH1A1MEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100087543-A1 | PHARMACEUTICAL USE OF SUBSTITUTED AMIDES | VTVX HOLDINGS II LLC | 2010-04-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100087543-A1 | PHARMACEUTICAL USE OF SUBSTITUTED AMIDES | HSD11B1, HSD17B1, HSD11B2 | HPGD 34/4885KMT2A 4062/4885ALDH1A1 751/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.