Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | CDK8 | P49336 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3076827 | 0.87 | GAA (0.65) | HTTKDM4EGAAKMT2AMEN1 | |
| SCHEMBL23043941 | 0.87 | GAA (0.65) | HTTKDM4EGAAKMT2AMEN1 | |
| SCHEMBL23123509 | 0.78 | ADRA2C (0.44) | HTTKDM4EGAAKMT2AMEN1 | |
| SCHEMBL23122730 | 0.77 | KEAP1 (0.61) | HTTKDM4EGAAKMT2AMEN1 | |
| SCHEMBL31172356 | 0.77 | KEAP1 (0.67) | HTTKDM4EGAAKMT2AMEN1 | |
| SCHEMBL23122959 | 0.76 | MAP4K4 (0.43) | KMT2AMEN1ADORA2AADORA1MAP4K4 | |
| SCHEMBL15365564 | 0.76 | KEAP1 (0.70) | HTTKDM4EGAAKMT2AMEN1 | |
| SCHEMBL31172297 | 0.76 | KEAP1 (0.70) | HTTKDM4EGAAKMT2AMEN1 | |
| SCHEMBL14217253 | 0.76 | KDM4E (0.53) | HTTKDM4EGAAUSP2MAPT | |
| SCHEMBL3559010 | 0.76 | MAPT (0.51) | HTTKDM4EGAAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7696210-B2 | Gonadotropin releasing hormone receptor antagonists | WYETH (US) | 2010-04-13 | — | — | US | disclosed |