Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.49 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | STAT3 | P40763 | 1/20 | 0.45 |
| ▸ | STAT1 | P42224 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.45 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13405530 | 0.88 | HTT (0.52) | PIM1ALDH1A1TSHRPOLBNPSR1 | |
| SCHEMBL13405531 | 0.86 | SMN1; SMN2 (0.58) | PIM1ALDH1A1TSHRPOLBALOX15 | |
| SCHEMBL13405516 | 0.85 | PIM1 (0.58) | PIM1ALDH1A1TSHRMAPK1SMN1; SMN2 | |
| SCHEMBL13405529 | 0.85 | PIM1 (0.52) | PIM1ALDH1A1TSHRALOX15MAPK1 | |
| SCHEMBL13405525 | 0.81 | PIM1 (0.58) | PIM1SMN1; SMN2MAPK9MAPK10SYK | |
| SCHEMBL13405517 | 0.81 | PIM1 (0.57) | PIM1ALDH1A1TSHRALOX15MAPK1 | |
| SCHEMBL13683355 | 0.79 | PIM1 (0.55) | PIM1IRAK4MAPK9MAPK10SYK | |
| SCHEMBL13405534 | 0.79 | PIM1 (0.55) | PIM1MAPK9MAPK10SYK | |
| SCHEMBL13405487 | 0.78 | ALDH1A1 (0.54) | PIM1ALDH1A1TSHRPOLBMAPK1 | |
| SCHEMBL13405489 | 0.77 | PIM1 (0.64) | PIM1MAPK1NPSR1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100081657-A1 | QUINOXALINES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-04-01 | — | — | US | disclosed |
| US-20100081657-A1 | QUINOXALINES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-04-01 | — | — | US | disclosed |
| US-7592340-B2 | Quinoxalines useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-09-22 | — | — | US | disclosed |
| US-7592340-B2 | Quinoxalines useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-09-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100081657-A1 | QUINOXALINES USEFUL AS INHIBITORS OF PROTEIN KINASES | MAP3K20, MAP4K2, MAP3K5 | PIM1 554/4885IRAK4 793/4885ALDH1A1 4364/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.