Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.52 |
| ▸ | MOK | Q9UQ07 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 5/20 | 0.44 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | ROS1 | P08922 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13405530 | 0.85 | HTT (0.52) | PIM1TSHRKDM4ELMNAHSD17B10 | |
| SCHEMBL13405532 | 0.85 | PIM1 (0.49) | PIM1TSHRKDM4EMAPK10MAPK9 | |
| SCHEMBL13405525 | 0.84 | PIM1 (0.58) | PIM1MOKMAPK10MAPK9RET | |
| SCHEMBL13405516 | 0.84 | PIM1 (0.58) | PIM1TSHRHPGDMAPK10MAPK9 | |
| SCHEMBL13405534 | 0.83 | PIM1 (0.55) | PIM1MOKMAPK10MAPK9RET | |
| SCHEMBL13683355 | 0.83 | PIM1 (0.55) | PIM1MOKMAPK10MAPK9RET | |
| SCHEMBL13405531 | 0.83 | SMN1; SMN2 (0.58) | PIM1TSHRKDM4ELMNAALDH1A1 | |
| SCHEMBL13405517 | 0.83 | PIM1 (0.57) | PIM1TSHRHPGDMAPK10MAPK9 | |
| SCHEMBL13405515 | 0.80 | EML4 (0.51) | PIM1MOKTSHRKDM4EHPGD | |
| SCHEMBL13405487 | 0.80 | ALDH1A1 (0.54) | PIM1TSHRKDM4EHPGDMAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100081657-A1 | QUINOXALINES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-04-01 | — | — | US | disclosed |
| US-20100081657-A1 | QUINOXALINES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-04-01 | — | — | US | disclosed |
| US-7592340-B2 | Quinoxalines useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-09-22 | — | — | US | disclosed |
| US-7592340-B2 | Quinoxalines useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-09-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100081657-A1 | QUINOXALINES USEFUL AS INHIBITORS OF PROTEIN KINASES | MAP3K20, MAP4K2, MAP3K5 | PIM1 554/4885MOK 160/4885TSHR 4512/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.