Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.31 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.31 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.31 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.31 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.31 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.31 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14103627 | 0.97 | SMN1; SMN2 (0.42) | SMN1; SMN2HPGDHTTALDH1A1SLC6A5 | |
| SCHEMBL13444441 | 0.91 | SMN1; SMN2 (0.45) | SMN1; SMN2HPGDHTTALDH1A1SLC6A5 | |
| SCHEMBL17767812 | 0.88 | SMN1; SMN2 (0.50) | SMN1; SMN2HPGDHTTALDH1A1TSHR | |
| SCHEMBL20999873 | 0.88 | SMN1; SMN2 (0.50) | SMN1; SMN2HPGDHTTALDH1A1TSHR | |
| SCHEMBL17767809 | 0.88 | SMN1; SMN2 (0.50) | SMN1; SMN2HPGDHTTALDH1A1TSHR | |
| SCHEMBL17168743 | 0.88 | SMN1; SMN2 (0.50) | SMN1; SMN2HPGDHTTALDH1A1TSHR | |
| SCHEMBL18827228 | 0.88 | SMN1; SMN2 (0.42) | SMN1; SMN2HPGDHTTALDH1A1SLC6A5 | |
| SCHEMBL21117960 | 0.87 | SMN1; SMN2 (0.49) | SMN1; SMN2HPGDHTTALDH1A1TSHR | |
| SCHEMBL30360564 | 0.85 | SMN1; SMN2 (0.38) | SMN1; SMN2HPGDHTTALDH1A1TSHR | |
| SCHEMBL12369355 | 0.84 | SMN1; SMN2 (0.50) | SMN1; SMN2HPGDHTTALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7700560-B2 | Inactivators and bivalent inhibitors of glyoxalase I and methods of inhibiting tumor growth | UNIVERSITY OF MARYLAND, BALTIMORE COUNTY (US) | 2010-04-20 | — | — | US | disclosed |
| US-20070129311-A1 | Inactivators and bivalent inhibitors of glyoxalase i and methods inhibiting tumor growth | UNIVERSITY OF MARYLAND, BALTIMORE COUNTY | 2007-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070129311-A1 | Inactivators and bivalent inhibitors of glyoxalase i and methods inhibiting tumor growth | GLS, GLO1, GLRX3 | SMN1; SMN2 4149/4885HPGD 188/4885HTT 3306/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.