SCHEMBL13412840

SCHEMBL13412840

C#CCN1CC(=O)N2[C@@H](Cc3ccc(O)cc3)C(=O)N(Cc3cccc4c3cnn4CCN3CCOCC3)[C@@H](C)[C@@H]2N1C(=O)NCc1ccccc1

nearest known ligand 0.47

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 19/20 0.47
TCF4 P15884 1/20 0.46
CTNNB1 P35222 1/20 0.46
CREBBP Q92793 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL749952 0.88 CYP3A4 (0.60) CYP3A4
SCHEMBL10260166 0.84 CYP3A4 (0.47) CYP3A4
SCHEMBL10227728 0.82 CYP3A4 (0.59) CYP3A4
SCHEMBL748674 0.80 CYP3A4 (0.60) CYP3A4TCF4CTNNB1CREBBP
SCHEMBL749388 0.78 TCF4 (0.47) CYP3A4TCF4CTNNB1CREBBP
SCHEMBL14515369 0.78 TCF4 (0.47) CYP3A4TCF4CTNNB1CREBBP
SCHEMBL12021312 0.77 TCF4 (0.47) CYP3A4TCF4CTNNB1CREBBP
SCHEMBL748673 0.76 CTNNB1 (0.55) CYP3A4TCF4CTNNB1CREBBP
SCHEMBL15962638 0.75 CTNNB1 (0.67) CYP3A4TCF4CTNNB1CREBBP
SCHEMBL29506801 0.75 CTNNB1 (0.67) CYP3A4TCF4CTNNB1CREBBP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7671054-B1 Reverse-turn mimetics and method relating thereto CHOONGWAE PHARMA CORPORATION (KR) 2010-03-02 US disclosed
US-7671054-B1 Reverse-turn mimetics and method relating thereto CHOONGWAE PHARMA CORPORATION (KR) 2010-03-02 US disclosed