Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 6/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 5/20 | 0.49 |
| ▸ | ESR1 | P03372 | 5/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.49 |
| ▸ | RNASEL | Q05823 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL916156 | 0.83 | HDAC4 (0.50) | TSHRLMNAESR1CYP1A2CYP2C19 | |
| SCHEMBL448074 | 0.78 | TSHR (0.59) | TSHRL3MBTL1TDP1LMNAESR1 | |
| SCHEMBL27908114 | 0.75 | CYP1A2 (0.47) | TSHRL3MBTL1TDP1LMNAESR1 | |
| SCHEMBL28424839 | 0.75 | TSHR (0.56) | TSHRL3MBTL1TDP1LMNAESR1 | |
| SCHEMBL28061402 | 0.74 | SOAT1 (0.44) | TSHRTDP1LMNACYP1A2CYP2C19 | |
| SCHEMBL28433114 | 0.73 | HDAC4 (0.59) | TSHRL3MBTL1TDP1LMNAESR1 | |
| SCHEMBL4066379 | 0.73 | — | — | |
| SCHEMBL27334972 | 0.73 | TSHR (0.46) | TSHRL3MBTL1TDP1LMNAESR1 | |
| SCHEMBL18154629 | 0.73 | TSHR (0.61) | TSHRL3MBTL1TDP1LMNAESR1 | |
| SCHEMBL136240 | 0.72 | TDP1 (0.56) | TSHRL3MBTL1TDP1LMNAESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104662024-A | Tyrosine Kinase Inhibitors | HOFFMANN LA ROCHE | 2015-05-27 | — | — | CN | disclosed |
| CN-102884063-A | Substituted aza-bicyclic imidazole derivatives useful as TRPM8 receptor modulators | JANSSEN PHARMACEUTICA NV | 2013-01-16 | — | — | CN | disclosed |
| US-7687496-B2 | C7-substituted camptothecin analogs | BIONUMERIK PHARMACEUTICALS, INC. (US) | 2010-03-30 | — | — | US | disclosed |
| US-20090099224-A1 | C7- substituted camptothecin analogs | BIONUMERIK PHARMACEUTICALS, INC. | 2009-04-16 | — | — | US | disclosed |
| CN-1046332-A | New compound | BEECHAM GROUP PLC (GB) | 1990-10-24 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090099224-A1 | C7- substituted camptothecin analogs | ABCB1, ABCC1, ABCG2 | TSHR 3342/4885L3MBTL1 1295/4885TDP1 1036/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.