Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY12 | Q9H244 | 10/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 4/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CCR8 | P51685 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13421244 | 0.92 | PPARG (0.41) | P2RY12PPARGFAAHKDM4EALDH1A1 | |
| SCHEMBL13421229 | 0.89 | PPARG (0.39) | PPARGFAAHKDM4EALDH1A1CHRM2 | |
| SCHEMBL13419963 | 0.87 | P2RY12 (0.51) | P2RY12PPARGCHRM3 | |
| SCHEMBL13419612 | 0.87 | PPARG (0.40) | PPARGFAAHKDM4EALDH1A1CHRM2 | |
| SCHEMBL13419966 | 0.86 | FAAH (0.43) | P2RY12PPARGKMT2AFAAHCCR8 | |
| SCHEMBL13419599 | 0.86 | CCR8 (0.42) | P2RY12PPARGTP53ALDH1A1CCR8 | |
| SCHEMBL13423057 | 0.85 | GSK3B (0.43) | PPARGKDM4ECHRM3 | |
| SCHEMBL13419717 | 0.85 | CCR8 (0.48) | PPARGCCR8 | |
| SCHEMBL13419619 | 0.85 | PIM1 (0.53) | P2RY12KMT2AALDH1A1MAPT | |
| SCHEMBL13455716 | 0.85 | EPHX2 (0.42) | PPARGFAAHCCR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7674803-B2 | Thiazolypiperidine derivatives as MTP inhibitors | MERCK PATENT GMBH (DE) | 2010-03-09 | — | — | US | disclosed |
| US-7674803-B2 | Thiazolypiperidine derivatives as MTP inhibitors | MERCK PATENT GMBH (DE) | 2010-03-09 | — | — | US | disclosed |