SCHEMBL3344725

SCHEMBL3344725

CS(=O)(=O)c1nc(Nc2ccc(F)c(Cl)c2)ncc1Br

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 1/20 0.50
CA1 P00915 1/20 0.50
CA2 P00918 1/20 0.50
CA9 Q16790 1/20 0.50
MAPK1 P28482 1/20 0.49
STK17A Q9UEE5 2/20 0.47
STK17B O94768 1/20 0.47
APP P05067 2/20 0.46
SOS1 Q07889 1/20 0.46
GLO1 Q04760 1/20 0.43
AXL P30530 2/20 0.42
PTGS1 P23219 1/20 0.42
PTGS2 P35354 1/20 0.42
ULK1 O75385 1/20 0.42
KCNH2 Q12809 1/20 0.42
CDK1 P06493 2/20 0.41
CDK2 P24941 2/20 0.41
KDR P35968 2/20 0.41
CSNK2A1 P68400 1/20 0.41
CSNK1A1 P48729 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3448927 0.90 CDK1 (0.44) CA2SOS1GLO1CDK1CDK2
SCHEMBL3450272 0.87 GRM4 (0.44) GLO1CDK1CDK2KDR
SCHEMBL3344933 0.81 MAPK1 (0.47) CA12CA1CA2CA9MAPK1
SCHEMBL3344858 0.81 MAPK1 (0.57) CA12CA1CA2CA9MAPK1
SCHEMBL3448567 0.80 HDAC3 (0.46) SOS1PTGS2CDK1CDK2KDR
SCHEMBL13310349 0.79 MAPK1 (0.54) CA12CA1CA2CA9MAPK1
SCHEMBL3345887 0.79 APP (0.45) CA12CA1CA2CA9MAPK1
SCHEMBL3344899 0.78 APP (0.54) CA12CA1CA2CA9MAPK1
SCHEMBL3350947 0.78 MAPK1 (0.51) CA12CA1CA2CA9MAPK1
SCHEMBL3344452 0.78 ABL1 (0.56) CA12CA1CA2CA9MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4323324-A1 MULTI-COMPONENT EPOXY RESIN MATERIAL WITH FINE FILLERS Hilti Aktiengesellschaft (LI) 2024-02-21 EP disclosed
WO-2024017661-A1 CHEMICAL ANCHOR SYSTEM HILTI AKTIENGESELLSCHAFT (LI) 2024-01-25 WO disclosed
EP-3526261-A1 BETA-NUCLEATED PROPYLENE TERPOLYMER COMPOSITION WITH GOOD TOUGHNESS Borealis AG (AT) 2019-08-21 EP disclosed
WO-2018069263-A1 BETA-NUCLEATED PROPYLENE TERPOLYMER COMPOSITION WITH GOOD TOUGHNESS BOREALIS AG (AT) 2018-04-19 WO disclosed
CN-102746584-A Pipes comprising beta-nucleated propylene copolymers BOREALIS TECH OY 2012-10-24 CN disclosed
US-20100137313-A1 HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF ASTRAZENECA AB 2010-06-03 US disclosed
US-20100137313-A1 HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF ASTRAZENECA AB 2010-06-03 US disclosed
US-20100137313-A1 HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF ASTRAZENECA AB 2010-06-03 US disclosed
WO-2010057841-A1 PROPYLENE-BUTENE RANDOM COPOLYMER PRODUCED IN THE PRESENCE OF A METTALOCENE CATALYST BOREALIS AG (AT) 2010-05-27 WO disclosed
WO-2010057840-A1 PROPYLENE-HEXENE RANDOM COPOLYMER PRODUCED IN THE PRESENCE OF A METALLOCENE CATALYST BOREALIS AG (AT) 2010-05-27 WO disclosed
WO-2010037747-A1 NEW SEWAGE PIPE MATERIAL WITH IMPROVED PROPERTIES BOREALIS AG (AT) 2010-04-08 WO disclosed
WO-2010038081-A2 HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF ASTRAZENECA AB (SE) 2010-04-08 WO disclosed
WO-2010038081-A2 HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF ASTRAZENECA AB (SE) 2010-04-08 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100137313-A1 HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF SDHA, SDHB, UROD CA12 1716/4885CA1 3580/4885CA2 1976/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.