Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.40 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.40 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.40 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.39 |
| ▸ | LCK | P06239 | 2/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.38 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3313360 | 0.88 | CSNK2A1 (0.45) | MAPK14MAPTKMT2AHTTL3MBTL1 | |
| SCHEMBL13421530 | 0.83 | TYK2 (0.41) | MAPK14CSNK2A1CSNK2A2CSNK2BLCK | |
| SCHEMBL13422030 | 0.81 | TYK2 (0.42) | MAPK14CSNK2A1CSNK2A2CSNK2BTYK2 | |
| SCHEMBL13421572 | 0.79 | KCNH2 (0.44) | MAPK14KMT2ACSNK2A1CSNK2A2CSNK2B | |
| SCHEMBL13421481 | 0.79 | TYK2 (0.55) | CSNK2A1CSNK2A2CSNK2BTYK2DYRK3 | |
| SCHEMBL13421552 | 0.77 | MAPK14 (0.42) | MAPK14TYK2 | |
| SCHEMBL13421762 | 0.76 | CDK2 (0.40) | MAPK14CSNK2A1CSNK2A2CSNK2BTYK2 | |
| SCHEMBL13421587 | 0.75 | KCNH2 (0.37) | MAPK14CSNK2A1CSNK2A2CSNK2BBRAF | |
| SCHEMBL13421889 | 0.74 | ABL1 (0.47) | MAPK14IRAK4LCKBRAFTYK2 | |
| SCHEMBL3311742 | 0.73 | CSNK2A1 (0.46) | MAPK14CSNK2A1CSNK2A2CSNK2BIRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010042699-A1 | IMIDAZOPYRIDAZINECARBONITRILES USEFUL AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-04-15 | — | — | WO | disclosed |