Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.50 |
| ▸ | MEN1 | O00255 | 5/20 | 0.50 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.47 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | OXTR | P30559 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13422229 | 0.80 | HSD11B1 (0.51) | OXTRALDH1A1MAPTTSHR | |
| SCHEMBL13455694 | 0.77 | DHODH (0.44) | TAS1R3TAS1R1ALDH1A1MAPTTSHR | |
| SCHEMBL13909775 | 0.76 | HSD11B1 (0.47) | OXTRPOLBALDH1A1MAPTTSHR | |
| SCHEMBL13422171 | 0.76 | HSD11B1 (0.47) | OXTRMAPTTSHR | |
| SCHEMBL13422231 | 0.76 | NPC1 (0.44) | KMT2AMEN1ALDH1A1MAPTTSHR | |
| SCHEMBL29694265 | 0.75 | HTT (0.53) | KMT2ATAS1R3TAS1R1ALDH1A1TSHR | |
| SCHEMBL3465075 | 0.72 | TSHR (0.44) | KMT2AMEN1TAS1R3TAS1R1POLB | |
| SCHEMBL3465072 | 0.72 | TSHR (0.44) | KMT2AMEN1TAS1R3TAS1R1POLB | |
| SCHEMBL17075789 | 0.72 | TSHR (0.43) | KMT2ATAS1R3TAS1R1ALDH1A1MAPT | |
| SCHEMBL20542696 | 0.71 | LMNA (0.45) | KMT2ATAS1R3TAS1R1POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7674803-B2 | Thiazolypiperidine derivatives as MTP inhibitors | MERCK PATENT GMBH (DE) | 2010-03-09 | — | — | US | disclosed |
| US-7674803-B2 | Thiazolypiperidine derivatives as MTP inhibitors | MERCK PATENT GMBH (DE) | 2010-03-09 | — | — | US | disclosed |