SCHEMBL13424948

SCHEMBL13424948

NC1=NC=NC2C1C(c1cccc(O)c1)=NN2Cc1cc2c(nc1-c1ccccc1F)CCC2

nearest known ligand 0.48

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PIK3CD O00329 2/20 0.48
PIK3CG P48736 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13424946 0.84 PIK3CD (0.44) PIK3CD
SCHEMBL13425212 0.79 PIK3CG (0.48) PIK3CDPIK3CG
SCHEMBL13425239 0.74 PIK3CD (0.43) PIK3CDPIK3CG
SCHEMBL13425245 0.73 PIK3CD (0.41) PIK3CDPIK3CG
SCHEMBL680990 0.72 PIK3CD (0.84) PIK3CDPIK3CG
SCHEMBL13425222 0.71 PIK3CG (0.35) PIK3CDPIK3CG
SCHEMBL13425220 0.69 MAPK1 (0.30)
SCHEMBL13425087 0.67 PIK3C2B (0.53) PIK3CDPIK3CG
SCHEMBL681827 0.66 PIK3CD (0.48) PIK3CD
SCHEMBL681824 0.66 PIK3CD (0.46) PIK3CD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010036380-A1 HETEROCYCLIC KINASE INHIBITORS INTELLIKINE, INC. (US) 2010-04-01 WO disclosed