Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPA1 | P27694 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | HPGD | P15428 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 5/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13425234 | 0.84 | KDM4E (0.53) | RPA1KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL30935867 | 0.78 | RPA1 (0.57) | RPA1KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL15180301 | 0.78 | RPA1 (0.57) | RPA1KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL6326045 | 0.75 | KDM4E (0.43) | RPA1KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL5756993 | 0.75 | RPA1 (0.48) | RPA1KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL21208437 | 0.74 | ZAP70 (0.41) | RPA1KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL22045245 | 0.73 | KDM4E (0.50) | RPA1KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL13425241 | 0.73 | RPA1 (0.44) | RPA1KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL22045667 | 0.72 | KDM4E (0.56) | RPA1KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL5753460 | 0.72 | RPA1 (0.43) | RPA1KDM4EALDH1A1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100063046-A1 | TETRACYCLIC IMIDAZOLE ANALOGS | SENHWA BIOSCIENCES, INC. (TW) | 2010-03-11 | — | — | US | disclosed |
| US-20100063046-A1 | TETRACYCLIC IMIDAZOLE ANALOGS | SENHWA BIOSCIENCES, INC. (TW) | 2010-03-11 | — | — | US | disclosed |
| WO-2008060693-A2 | TETRACYCLIC IMIDAZOLE ANALOGS | CYLENE PHARMACEUTICALS, INC. (US) | 2008-05-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100063046-A1 | TETRACYCLIC IMIDAZOLE ANALOGS | BAD, API5, MCL1 | RPA1 2674/4885KDM4E 1375/4885ALDH1A1 3035/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.