Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPA1 | P27694 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30935867 | 0.77 | RPA1 (0.57) | RPA1KDM4EALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL15180301 | 0.77 | RPA1 (0.57) | RPA1KDM4EALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL5753460 | 0.76 | RPA1 (0.43) | RPA1KDM4EALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL5753462 | 0.76 | PDE5A (0.32) | ALDH1A1DDB1CRBN | |
| SCHEMBL5761830 | 0.76 | PIK3CD (0.36) | ALDH1A1MEN1KMT2A | |
| SCHEMBL5761826 | 0.75 | KDM4E (0.45) | RPA1KDM4EALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL13425234 | 0.75 | KDM4E (0.53) | RPA1KDM4EALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL13425232 | 0.75 | RPA1 (0.49) | RPA1KDM4EALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL23504050 | 0.75 | KDM4E (0.46) | RPA1KDM4EALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL6326048 | 0.74 | CDK4 (0.34) | ALDH1A1HSD17B10MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1664053-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2006-06-07 | — | — | EP | claimed |
| WO-2005021551-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2005-03-10 | — | — | WO | claimed |
| EP-1664053-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2006-06-07 | — | — | EP | disclosed |
| US-20050070554-A1 | Substituted heterocyclic compounds and methods of use | AMGEN INC. | 2005-03-31 | — | — | US | disclosed |
| US-6872435-B2 | Multi-component unidirectional graphic article | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2005-03-29 | — | — | US | disclosed |
| WO-2005021551-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2005-03-10 | — | — | WO | disclosed |
| US-20010006714-A1 | Multi-component unidirectional graphic article | 3M INNOVATIVE PROPERTIES COMPANY | 2001-07-05 | — | — | US | disclosed |
| EP-1105288-A1 | MULTI-COMPONENT UNIDIRECTIONAL GRAPHIC ARTICLE | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 2001-06-13 | — | — | EP | disclosed |
| WO-1999065680-A1 | MULTI-COMPONENT UNIDIRECTIONAL GRAPHIC ARTICLE | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1999-12-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050070554-A1 | Substituted heterocyclic compounds and methods of use | NFATC1, ICOS, PAICS | RPA1 4186/4885KDM4E 3392/4885ALDH1A1 774/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.