Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.32 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL939 | 0.77 | SMN1; SMN2 (0.38) | SMN1; SMN2PKMLMNAALDH1A1MAPT | |
| SCHEMBL10871178 | 0.74 | PKM (0.56) | PKMLMNAALDH1A1MAPT | |
| SCHEMBL798 | 0.73 | KDM4E (0.36) | SMN1; SMN2LMNAALDH1A1MAPT | |
| SCHEMBL9383028 | 0.66 | SMN1; SMN2 (0.35) | SMN1; SMN2PKM | |
| SCHEMBL20552007 | 0.64 | GAA (0.40) | SMN1; SMN2LMNAALDH1A1MAPT | |
| SCHEMBL2183233 | 0.64 | L3MBTL1 (0.42) | LMNAALDH1A1MAPT | |
| SCHEMBL10918310 | 0.63 | MAPT (0.42) | SMN1; SMN2PKMLMNAALDH1A1MAPT | |
| SCHEMBL1075833 | 0.62 | PKM (0.61) | SMN1; SMN2PKMLMNAALDH1A1MAPT | |
| SCHEMBL1559564 | 0.60 | MAPT (0.43) | SMN1; SMN2PKMLMNAALDH1A1MAPT | |
| SCHEMBL27591379 | 0.60 | SMN1; SMN2 (0.41) | SMN1; SMN2PKMLMNAALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6200980-B1 | ADMINISTERING PHENYL PURINONE COMPOUND FOR TREATING PRECANCEROUS LEISONS | CELL PATHWAYS, INC. | 2001-03-13 | — | — | US | disclosed |
| US-5719283-A | INHIBITORS OF PHOSPHODIESTERASES; CARDIOVASCULAR DISORDERS | PFIZER INC. (US) | 1998-02-17 | — | — | US | disclosed |
| EP-0463756-B1 | Pyrazolopyrimidinone antianginal agents | PFIZER LTD (GB) | 1995-04-19 | — | — | EP | disclosed |
| US-5346901-A | Treatment of angina, hypertension, heart failure and atherosclerosis | PFIZER INC. (US) | 1994-09-13 | — | — | US | disclosed |
| US-5250534-A | Inhibitors of cyclic guanosine 3*,5*-monophosphate phosphodiesterase | PFIZER INC. (US) | 1993-10-05 | — | — | US | disclosed |
| EP-0463756-A1 | Pyrazolopyrimidinone antianginal agents | Pfizer Limited (GB) | 1992-01-02 | — | — | EP | disclosed |