Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | SUCNR1 | Q9BXA5 | 5/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARD | Q03181 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.40 |
| ▸ | KDM4A | O75164 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3418641 | 0.86 | ALDH1A1 (0.45) | ALDH1A1HPGDKDM4EMEN1LMNA | |
| SCHEMBL3416346 | 0.83 | PPARG (0.53) | ALDH1A1HPGDKDM4EHTTSMN1; SMN2 | |
| SCHEMBL4718383 | 0.82 | SCN9A (0.47) | ALDH1A1HPGDKDM4EMEN1LMNA | |
| SCHEMBL13433262 | 0.80 | HDAC1 (0.48) | KDM4ESMN1; SMN2PPARGPPARDPPARA | |
| SCHEMBL3413999 | 0.79 | EGFR (0.41) | ALDH1A1HPGDKDM4ELMNAHTT | |
| SCHEMBL3415307 | 0.79 | PPARD (0.63) | ALDH1A1HPGDKDM4EMEN1LMNA | |
| SCHEMBL13433269 | 0.78 | CYP11B1 (0.50) | PPARGPPARDPPARADYRK1A | |
| SCHEMBL3415566 | 0.78 | PPARD (0.40) | ALDH1A1HPGDKDM4ELMNAHTT | |
| SCHEMBL4722006 | 0.77 | MAPK1 (0.57) | ALDH1A1HPGDKDM4EMEN1HTT | |
| SCHEMBL3413967 | 0.77 | BDKRB1 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7687664-B2 | Carboxylic acid derivative, a salt thereof or an ester of them, and medicament comprising it | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2010-03-30 | — | — | US | disclosed |
| US-7687664-B2 | Carboxylic acid derivative, a salt thereof or an ester of them, and medicament comprising it | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2010-03-30 | — | — | US | disclosed |