Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 4/20 | 0.48 |
| ▸ | ACACB | O00763 | 1/20 | 0.47 |
| ▸ | ACACA | Q13085 | 1/20 | 0.47 |
| ▸ | KDM1A | O60341 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | KDM6B | O15054 | 1/20 | 0.45 |
| ▸ | KDM5C | P41229 | 1/20 | 0.45 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.45 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.45 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.45 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.41 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARD | Q03181 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | CFTR | P13569 | 1/20 | 0.41 |
| ▸ | AAK1 | Q2M2I8 | 4/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3416346 | 0.88 | PPARG (0.53) | HDAC1KDM4EPPARGPPARDPPARA | |
| SCHEMBL3416551 | 0.85 | HDAC1 (0.50) | HDAC1KDM1AKDM4EKDM6BKDM5C | |
| SCHEMBL13433269 | 0.83 | CYP11B1 (0.50) | HDAC1KDM1APPARGPPARDPPARA | |
| SCHEMBL3413912 | 0.82 | PPARD (0.42) | HDAC1PPARGPPARDPPARASMN1; SMN2 | |
| SCHEMBL3415050 | 0.81 | PPARD (0.41) | HDAC1PPARGPPARDPPARA | |
| SCHEMBL3414304 | 0.81 | PPARD (0.43) | HDAC1PPARGPPARDPPARA | |
| SCHEMBL3417162 | 0.80 | BDKRB1 (0.42) | PPARGPPARDPPARASMN1; SMN2 | |
| SCHEMBL3416623 | 0.80 | KDM4E (0.41) | KDM4EPPARGPPARDPPARASMN1; SMN2 | |
| SCHEMBL13433259 | 0.80 | ALDH1A1 (0.45) | KDM4EPPARGPPARDPPARASMN1; SMN2 | |
| SCHEMBL3413999 | 0.80 | EGFR (0.41) | HDAC1KDM4EPPARGPPARDPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7687664-B2 | Carboxylic acid derivative, a salt thereof or an ester of them, and medicament comprising it | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2010-03-30 | — | — | US | disclosed |
| US-7687664-B2 | Carboxylic acid derivative, a salt thereof or an ester of them, and medicament comprising it | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2010-03-30 | — | — | US | disclosed |