Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN2A | Q99250 | 1/20 | 0.43 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PPARD | Q03181 | 5/20 | 0.41 |
| ▸ | PPARA | Q07869 | 2/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.40 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | SHMT1 | P34896 | 1/20 | 0.38 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | VEGFA | P15692 | 1/20 | 0.37 |
| ▸ | FLT1 | P17948 | 1/20 | 0.37 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.37 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3418619 | 0.91 | SCN2A (0.45) | SCN2ASCN10ALMNAPPARDHCRTR1 | |
| SCHEMBL3413468 | 0.88 | PPARD (0.54) | PPARDPPARA | |
| SCHEMBL3415713 | 0.88 | PPARD (0.53) | SCN2ASCN10ALMNAPPARDPPARA | |
| SCHEMBL13461077 | 0.85 | SCN2A (0.44) | SCN2ASCN10ALMNAPPARDPPARA | |
| SCHEMBL3417420 | 0.83 | PTPN11 (0.43) | SCN2ASCN10ALMNAPPARDHPGD | |
| SCHEMBL3413883 | 0.83 | ALDH1A1 (0.41) | SCN2ASCN10ALMNAPPARDEGLN1 | |
| SCHEMBL13433441 | 0.82 | PPARD (0.56) | PPARDPPARA | |
| SCHEMBL13433429 | 0.81 | PPARD (0.47) | LMNAPPARDPPARA | |
| SCHEMBL3415588 | 0.81 | HPGD (0.48) | LMNAHCRTR1AKR1B1CTSBSHMT1 | |
| SCHEMBL3415410 | 0.79 | SCN2A (0.50) | SCN2ASCN10ALMNAPPARDPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7687664-B2 | Carboxylic acid derivative, a salt thereof or an ester of them, and medicament comprising it | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2010-03-30 | — | — | US | disclosed |
| US-7687664-B2 | Carboxylic acid derivative, a salt thereof or an ester of them, and medicament comprising it | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2010-03-30 | — | — | US | disclosed |