Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 2/20 | 0.50 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.50 |
| ▸ | RXRA | P19793 | 2/20 | 0.50 |
| ▸ | PPARD | Q03181 | 4/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 8/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.43 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.43 |
| ▸ | PTGDR | Q13258 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | PTGIR | P43119 | 1/20 | 0.42 |
| ▸ | RXRB | P28702 | 1/20 | 0.41 |
| ▸ | RXRG | P48443 | 1/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13433603 | 0.85 | FFAR1 (0.41) | NR1H2NR1H3RXRAPPARDPTGDR2 | |
| SCHEMBL3416970 | 0.80 | RXRA (0.47) | NR1H2NR1H3RXRAPPARDPTGDR2 | |
| SCHEMBL3416294 | 0.77 | PTGDR2 (0.69) | NR1H2NR1H3RXRAPPARDPTGDR2 | |
| SCHEMBL3412374 | 0.76 | NR1H2 (0.50) | NR1H2NR1H3RXRAPPARDPTGDR2 | |
| SCHEMBL6267349 | 0.75 | PSEN1 (0.64) | NR1H2NR1H3RXRAPPARDFFAR1 | |
| SCHEMBL3415371 | 0.75 | MGLL (0.51) | NR1H2NR1H3RXRAPPARDPTGDR2 | |
| SCHEMBL3413762 | 0.73 | NR1H2 (0.55) | NR1H2NR1H3RXRAPPARDFFAR1 | |
| SCHEMBL3415287 | 0.73 | PTGDR2 (0.64) | NR1H2NR1H3RXRAPPARDPTGDR2 | |
| SCHEMBL3413908 | 0.73 | RXRA (0.47) | NR1H2NR1H3RXRAPPARDPTGDR2 | |
| SCHEMBL6719678 | 0.73 | NR1H2 (0.45) | NR1H2NR1H3RXRAPPARDPTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7687664-B2 | Carboxylic acid derivative, a salt thereof or an ester of them, and medicament comprising it | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2010-03-30 | — | — | US | disclosed |
| US-7687664-B2 | Carboxylic acid derivative, a salt thereof or an ester of them, and medicament comprising it | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2010-03-30 | — | — | US | disclosed |