Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 10/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | VNN1 | O95497 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 5/20 | 0.36 |
| ▸ | FAP | Q12884 | 3/20 | 0.36 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.36 |
| ▸ | PREP | P48147 | 2/20 | 0.36 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.36 |
| ▸ | PITRM1 | Q5JRX3 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | REN | P00797 | 1/20 | 0.36 |
| ▸ | ACE | P12821 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12584819 | 0.84 | POLB (0.39) | POLBL3MBTL1CA12CA1CA2 | |
| SCHEMBL642427 | 0.84 | F2 (0.44) | DPP4 | |
| SCHEMBL608859 | 0.84 | F2 (0.44) | DPP4 | |
| SCHEMBL606217 | 0.84 | F2 (0.44) | DPP4 | |
| SCHEMBL21102001 | 0.81 | DPP4 (0.39) | DPP4CA12CA1CA2CA9 | |
| SCHEMBL425457 | 0.80 | DPP4 (0.40) | DPP4VNN1CA12CA1CA2 | |
| SCHEMBL3817074 | 0.79 | HTT (0.45) | DPP4CA12CA1CA2CA9 | |
| SCHEMBL22296753 | 0.79 | POLB (0.33) | POLBL3MBTL1CA12CA1CA2 | |
| SCHEMBL8591233 | 0.79 | HTT (0.45) | DPP4CA12CA1CA2CA9 | |
| SCHEMBL30305372 | 0.79 | HTT (0.45) | DPP4CA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2177523-A1 | Novel macrocyclic inhibitors of hepatitis c virus replication | Intermune, Inc. (US) | 2010-04-21 | — | — | EP | disclosed |