Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 4/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
| ▸ | IL6 | P05231 | 1/20 | 0.43 |
| ▸ | STAT3 | P40763 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13436641 | 0.83 | FAAH (0.58) | FAAHHDAC6NPC1GAARAB9A | |
| SCHEMBL13436687 | 0.79 | FAAH (0.59) | FAAHHDAC6 | |
| SCHEMBL3475836 | 0.79 | NPC1 (0.56) | FAAHHDAC6NPC1GAARAB9A | |
| SCHEMBL3476760 | 0.79 | FAAH (0.56) | FAAHHDAC6NPC1GAARAB9A | |
| SCHEMBL3475389 | 0.79 | FAAH (0.53) | FAAHHDAC6NPC1GAARAB9A | |
| SCHEMBL3475208 | 0.76 | FAAH (0.61) | FAAHHDAC6NPC1GAARAB9A | |
| SCHEMBL3475856 | 0.76 | FAAH (0.65) | FAAHHDAC6NPC1GAARAB9A | |
| SCHEMBL3475433 | 0.75 | FAAH (0.57) | FAAHHDAC6NPC1GAARAB9A | |
| SCHEMBL13436714 | 0.75 | FAAH (0.60) | FAAHHDAC6NPC1GAARAB9A | |
| SCHEMBL13436702 | 0.74 | FAAH (0.61) | FAAHHDAC6NPC1GAARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010039186-A2 | COMPOUNDS USEFUL AS FAAH MODULATORS AND USES THEREOF | RENOVIS, INC. (US) | 2010-04-08 | — | — | WO | disclosed |