Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 14/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 9/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.50 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3612375 | 0.83 | OPRM1 (0.61) | OPRL1OPRM1OPRK1OPRD1 | |
| SCHEMBL6580420 | 0.79 | CHRM2 (0.50) | OPRL1OPRM1OPRK1OPRD1KCNH2 | |
| SCHEMBL4865936 | 0.78 | OPRL1 (0.54) | OPRL1OPRM1OPRK1 | |
| SCHEMBL6212768 | 0.77 | HTR4 (0.42) | OPRL1OPRM1OPRK1 | |
| SCHEMBL3620583 | 0.76 | HTR4 (0.41) | OPRL1OPRM1OPRK1 | |
| SCHEMBL13437100 | 0.75 | CHRM1 (0.68) | OPRL1OPRM1OPRK1 | |
| SCHEMBL1865241 | 0.75 | OPRL1 (0.52) | OPRL1OPRM1OPRK1 | |
| SCHEMBL3617803 | 0.75 | OPRL1 (0.68) | OPRL1OPRM1OPRK1 | |
| SCHEMBL1858426 | 0.74 | OPRL1 (0.60) | OPRL1OPRM1OPRK1OPRD1 | |
| SCHEMBL6577940 | 0.74 | CHRM1 (0.67) | OPRL1OPRM1OPRK1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678809-B2 | Benzimidazole compounds having nociceptin receptor affinity | PURDUE PHARMA L.P. (US) | 2010-03-16 | — | — | US | disclosed |
| US-7678809-B2 | Benzimidazole compounds having nociceptin receptor affinity | PURDUE PHARMA L.P. (US) | 2010-03-16 | — | — | US | disclosed |
| US-7456198-B2 | Useful in the treatment of chronic and acute pain. | PURDUE PHARMA L.P. (US) | 2008-11-25 | — | — | US | disclosed |