Sugi Predict

Sugi Predict / Compounds / SCHEMBL13438475

SCHEMBL13438475

SCHEMBL13438475

COc1cc2c(c(OC)c1OC)-c1ccc(SC)c(=O)cc1[C@@H](NC(=O)[C@@H]1CCC[C@H](C(=O)N[C@H]3CCc4cc(OC)c(OC)c(OC)c4-c4ccc(SC)c(=O)cc43)C1)CC2

nearest known ligand 0.78

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ TUBB4A P04350 16/20 0.78
▸ TUBB P07437 16/20 0.78
▸ TUBA3C P0DPH7 16/20 0.78
▸ TUBA1B P68363 16/20 0.78
▸ TUBA4A P68366 16/20 0.78
▸ TUBB4B P68371 16/20 0.78
▸ TUBB3 Q13509 16/20 0.78
▸ TUBB2A Q13885 16/20 0.78
▸ TUBB8 Q3ZCM7 16/20 0.78
▸ TUBA3E Q6PEY2 16/20 0.78
▸ TUBA1A Q71U36 16/20 0.78
▸ TUBA1C Q9BQE3 16/20 0.78
▸ TUBB6 Q9BUF5 16/20 0.78
▸ TUBB2B Q9BVA1 16/20 0.78
▸ TUBB1 Q9H4B7 16/20 0.78

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13438478 1.00 TUBB4A (0.78) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL13438474 0.93 TUBB4A (0.83) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL13438480 0.92 TUBB4A (0.77) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL14132094 0.92 TUBB4A (0.77) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL13622202 0.89 TUBB4A (0.79) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL13622196 0.89 TUBB4A (0.79) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL13438483 0.89 TUBB4A (0.88) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
Thiocolchicine SCHEMBL43161 0.88 TUBB1 (1.00) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
Thiocolchicine SCHEMBL43160 0.88 TUBB1 (1.00) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL13693049 0.87 TUBB4A (0.84) TUBB4ATUBBTUBA3CTUBA1BTUBA4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7687545-B2 N-deacetylthiocolchicine derivatives, their use and pharmaceutical formulations containing them INDENA S.P.A. (IT) 2010-03-30 — — US disclosed
US-7687545-B2 N-deacetylthiocolchicine derivatives, their use and pharmaceutical formulations containing them INDENA S.P.A. (IT) 2010-03-30 — — US disclosed
US-7582639-B2 N-deacetylthiocolchicine derivatives, their use and pharmaceutical formulations containing them INDENA S.P.A. (IT) 2009-09-01 — — US disclosed
US-7582639-B2 N-deacetylthiocolchicine derivatives, their use and pharmaceutical formulations containing them INDENA S.P.A. (IT) 2009-09-01 — — US disclosed
US-7579364-B2 N-deacetylthiocolchicine derivatives, their use and pharmaceutical formulations containing them INDENA S.P.A. (IT) 2009-08-25 — — US disclosed
US-7579364-B2 N-deacetylthiocolchicine derivatives, their use and pharmaceutical formulations containing them INDENA S.P.A. (IT) 2009-08-25 — — US disclosed
US-20080287499-A1 N-DEACETYLTHIOCOLCHICINE DERIATIVES, THEIR USE AND PHARMACEUTICAL FORMULATIONS CONTAINING THEM INDENA S.P.A. (IT) 2008-11-20 — — US disclosed
US-20080287499-A1 N-DEACETYLTHIOCOLCHICINE DERIATIVES, THEIR USE AND PHARMACEUTICAL FORMULATIONS CONTAINING THEM INDENA S.P.A. (IT) 2008-11-20 — — US disclosed
US-20080269292-A1 N-DEACETYLTHIOCOLCHICINE DERIATIVES, THEIR USE AND PHARMACEUTICAL FORMULATIONS CONTAINING THEM INDENA S.P.A. (IT) 2008-10-30 — — US disclosed
US-20080269292-A1 N-DEACETYLTHIOCOLCHICINE DERIATIVES, THEIR USE AND PHARMACEUTICAL FORMULATIONS CONTAINING THEM INDENA S.P.A. (IT) 2008-10-30 — — US disclosed
US-20080255151-A1 N-DEACETYLTHIOCOLCHICINE DERIATIVES, THEIR USE AND PHARMACEUTICAL FORMULATIONS CONTAINING THEM INDENA S.P.A. (IT) 2008-10-16 — — US disclosed
US-20080255151-A1 N-DEACETYLTHIOCOLCHICINE DERIATIVES, THEIR USE AND PHARMACEUTICAL FORMULATIONS CONTAINING THEM INDENA S.P.A. (IT) 2008-10-16 — — US disclosed
US-7399788-B2 N-deacetylthiocolchicine derivatives, their use and pharmaceutical formulations containing them INDENA S.P.A. (IT) 2008-07-15 — — US disclosed
US-7399788-B2 N-deacetylthiocolchicine derivatives, their use and pharmaceutical formulations containing them INDENA S.P.A. (IT) 2008-07-15 — — US disclosed
US-20070191486-A1 N-deacetylthiocolchicine derivatives, their use and pharmaceutical formulations containing them INDENA S.P.A. (IT) 2007-08-16 — — US disclosed
US-20070191486-A1 N-deacetylthiocolchicine derivatives, their use and pharmaceutical formulations containing them INDENA S.P.A. (IT) 2007-08-16 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070191486-A1 N-deacetylthiocolchicine derivatives, their use and pharmaceutical formulations containing them C9, CCNA2, CCNT1 TUBB4A 1943/4885TUBB 1581/4885TUBA3C 486/4885
US-20080269292-A1 N-DEACETYLTHIOCOLCHICINE DERIATIVES, THEIR USE AND PHARMACEUTICAL FORMULATIONS CONTAINING THEM C9, CCNT2, CCNT1 TUBB4A 2399/4885TUBB 2124/4885TUBA3C 852/4885
US-20080287499-A1 N-DEACETYLTHIOCOLCHICINE DERIATIVES, THEIR USE AND PHARMACEUTICAL FORMULATIONS CONTAINING THEM CCNT1, CCNT2, C9 TUBB4A 2099/4885TUBB 1866/4885TUBA3C 704/4885
US-20080255151-A1 N-DEACETYLTHIOCOLCHICINE DERIATIVES, THEIR USE AND PHARMACEUTICAL FORMULATIONS CONTAINING THEM CCNT1, CCNT2, C9 TUBB4A 2099/4885TUBB 1866/4885TUBA3C 704/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.