Thiocolchicine

Thiocolchicine

SCHEMBL43160

COc1cc2c(c(OC)c1OC)-c1ccc(SC)c(=O)cc1[C@@H](NC(C)=O)CC2

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TUBB1 Q9H4B7 9/20 1.00
TUBB4A P04350 8/20 1.00
TUBB P07437 8/20 1.00
TUBA3C P0DPH7 8/20 1.00
TUBA1B P68363 8/20 1.00
TUBA4A P68366 8/20 1.00
TUBB4B P68371 8/20 1.00
TUBB3 Q13509 8/20 1.00
TUBB2A Q13885 8/20 1.00
TUBB8 Q3ZCM7 8/20 1.00
TUBA3E Q6PEY2 8/20 1.00
TUBA1A Q71U36 8/20 1.00
TUBA1C Q9BQE3 8/20 1.00
TUBB6 Q9BUF5 8/20 1.00
TUBB2B Q9BVA1 8/20 1.00
LMNA P02545 2/20 0.80
CYP2C9 P11712 2/20 0.80
TSHR P16473 2/20 0.80
MITF O75030 1/20 0.80
KMT2A Q03164 1/20 0.80

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Thiocolchicine SCHEMBL43161 1.00 TUBB1 (1.00) TUBB1TUBB4ATUBBTUBA3CTUBA1B
Colchicine SCHEMBL2723855 0.97 TUBB1 (0.95) TUBB1TUBB4ATUBBTUBA3CTUBA1B
SCHEMBL12402699 0.94 TUBB1 (0.88) TUBB1TUBB4ATUBBTUBA3CTUBA1B
SCHEMBL13438483 0.93 TUBB4A (0.88) TUBB1TUBB4ATUBBTUBA3CTUBA1B
SCHEMBL2146845 0.93 TUBB1 (1.00) TUBB1TUBB4ATUBBTUBA3CTUBA1B
SCHEMBL12831823 0.93 TUBB1 (1.00) TUBB1TUBB4ATUBBTUBA3CTUBA1B
SCHEMBL23293732 0.92 TUBB1 (0.85) TUBB1TUBB4ATUBBTUBA3CTUBA1B
SCHEMBL12091271 0.92 TUBB1 (0.85) TUBB1TUBB4ATUBBTUBA3CTUBA1B
SCHEMBL13693049 0.92 TUBB4A (0.84) TUBB1TUBB4ATUBBTUBA3CTUBA1B
SCHEMBL13438474 0.91 TUBB4A (0.83) TUBB1TUBB4ATUBBTUBA3CTUBA1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 3638 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260137636-A1 TUMOR-TARGETING THIOCOLCHICINE NANOEMULSION SMITH HENRY (US) 2026-05-21 US claimed
US-20260116861-A1 ISOXAZOLE HYDROXAMIC ACIDS AS HISTONE DEACETYLASE 6 INHIBITORS THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION (US) 2026-04-30 US claimed
US-12522572-B2 Isoxazole hydroxamic acids as histone deacetylase 6 inhibitors THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION (US) 2026-01-13 US claimed
US-20250325717-A1 ANTI-NUCLEOPHOSMIN 1 ANTIBODY AND ANTIBODY CONJUGATE COMBINATION THERAPIES THE CHILDREN'S MEDICAL CENTER CORPORATION (US) 2025-10-23 US claimed
US-20250313647-A1 MUTANT AND MISLOCALIZED CELL SURFACE NUCLEOPHOSMIN 1 AS A DIAGNOSTIC AND THERAPEUTIC TARGET OF HUMAN DISEASE THE CHILDREN'S MEDICAL CENTER CORPORATION (US) 2025-10-09 US claimed
US-20250288535-A1 INSTANT NANOPARTICLE COMPOSITION AND PREPARATION METHOD THEREFOR CSPC ZHONGQI PHARMACEUTICAL TECHNOLOGY (SHIJIAZHUANG) CO., LTD. (CN) 2025-09-18 US claimed
EP-4590346-A1 FIBROBLAST ACTIVATION PROTEIN (FAP) INHIBITORS, FAP CONJUGATES, AND DIAGNOSTIC AND THERAPEUTIC USES THEREOF Nuclidium AG (CH) 2025-07-30 EP claimed
EP-4580677-A2 SARS-COV2 ANTIBODIES AND USES THEREOF Invivyd, Inc. (US) 2025-07-09 EP claimed
CN-119677779-A Combination therapy with anti-nucleolin 1 antibodies and antibody conjugates 儿童医学中心公司 2025-03-21 CN claimed
EP-4514857-A2 ANTI-NUCLEOPHOSMIN 1 ANTIBODY AND ANTIBODY CONJUGATE COMBINATION THERAPIES The Children's Medical Center Corporation (US) 2025-03-05 EP claimed
US-20030232837-A1 17-Beta hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases SCHERING CORPORATION 2003-12-18 US claimed
CN-1122657-C Colchicine-skeleton compounds, their use as medicaments and compounds containing them INDENA SPA (IT) 2003-10-01 CN claimed
EP-1313725-A1 TRICYCLIC ANTITUMOR COMPOUNDS BEING FARNESYL PROTEIN TRANSFERASE INHIBITORS SCHERING CORPORATION (US) 2003-05-28 EP claimed
WO-2003033487-A1 PIPERIDINE- AND PIPERAZINEACETAMINES AS 17BETA HYDROXYSTEROID DEHYDROGENASE TYPE 3 INHIBITORS FOR THE TREATMENT OF ANDROGEN DEPENDENT DISEASES SCHERING CORPORATION (US) 2003-04-24 WO claimed
WO-2003028527-A2 DIAGNOSTIC OR THERAPEUTIC SOMATOSTATIN OR BOMBESIN ANALOG CONJUGATES AND USES THEREOF THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND (US) 2003-04-10 WO claimed
WO-2003022835-A1 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 3 INHIBITORS FOR THE TREATMENT OF ANDROGEN DEPENDENT DISEASES SCHERING CORPORATION (US) 2003-03-20 WO claimed
US-20020198216-A1 Novel farnesyl protein transferase inhibitors as antitumor agents PHARMACOPEIA DRUG DISCOVERY 2002-12-26 US claimed
WO-2002018368-A1 TRICYCLIC ANTITUMOR COMPOUNDS BEING FARNESYL PROTEIN TRANSFERASE INHIBITORS SCHERING CORPORATION (US) 2002-03-07 WO claimed
CN-1219924-A Colchicine-skeleton compounds, their use as medicaments and compounds containing them INDENA SPA (IT) 1999-06-16 CN claimed
US-4533675-A ANTITUMOR, ANTICARCINOGENIC, ANTIARTHRITIC AGENTS THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1985-08-06 US claimed