Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MERTK | Q12866 | 6/20 | 0.47 |
| ▸ | TYRO3 | Q06418 | 6/20 | 0.47 |
| ▸ | AXL | P30530 | 5/20 | 0.47 |
| ▸ | FLT3 | P36888 | 2/20 | 0.44 |
| ▸ | GAS6 | Q14393 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11934855 | 1.00 | MERTK (0.47) | MERTKTYRO3AXLFLT3GAS6 | |
| SCHEMBL13438714 | 0.83 | MAPK1 (0.46) | MERTKTYRO3AXLFLT3GAS6 | |
| SCHEMBL11934841 | 0.83 | MAPK1 (0.46) | MERTKTYRO3AXLFLT3GAS6 | |
| SCHEMBL13565593 | 0.79 | MEN1 (0.36) | MERTKTYRO3AXLMEN1KMT2A | |
| SCHEMBL13564763 | 0.79 | CNR2 (0.37) | MERTKTYRO3AXLMEN1KMT2A | |
| SCHEMBL17089955 | 0.79 | CNR2 (0.37) | MERTKTYRO3AXLMEN1KMT2A | |
| SCHEMBL13438727 | 0.78 | MERTK (0.39) | MERTKTYRO3AXLFLT3GAS6 | |
| SCHEMBL11934854 | 0.78 | MERTK (0.39) | MERTKTYRO3AXLFLT3GAS6 | |
| SCHEMBL11934851 | 0.78 | THRB (0.46) | MERTKTYRO3AXLFLT3GAS6 | |
| SCHEMBL13438715 | 0.78 | THRB (0.46) | MERTKTYRO3AXLFLT3GAS6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9150507-B2 | Amine derivative having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2015-10-06 | — | — | US | disclosed |
| US-9150507-B2 | Amine derivative having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2015-10-06 | — | — | US | disclosed |
| US-20100063027-A1 | Amine Derivative Having NPY Y5 Receptor Antagonistic Activity | SHIONOGI & CO., LTD. (JP) | 2010-03-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100063027-A1 | Amine Derivative Having NPY Y5 Receptor Antagonistic Activity | NPY5R, NPY1R, NPY2R | MERTK 1503/4885TYRO3 152/4885AXL 469/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.