Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1238556 | 0.75 | — | — | |
| Hydrochloric Acid SCHEMBL7122089 | 0.73 | ALDH1A1 (0.48) | ALDH1A1GAATDP1EPHX2NPC1 | |
| SCHEMBL8075883 | 0.70 | ALDH1A1 (0.46) | ALDH1A1GAATDP1EPHX2NPC1 | |
| SCHEMBL13127107 | 0.70 | ALDH1A1 (0.46) | ALDH1A1GAATDP1EPHX2NPC1 | |
| SCHEMBL13158879 | 0.67 | EPHX2 (0.49) | ALDH1A1GAATDP1EPHX2NPC1 | |
| SCHEMBL4602458 | 0.67 | ALDH1A1 (0.38) | ALDH1A1GAATDP1KDM4ELMNA | |
| SCHEMBL14176519 | 0.67 | — | — | |
| SCHEMBL6036760 | 0.67 | KDM4E (0.43) | ALDH1A1GAATDP1EPHX2KDM4E | |
| SCHEMBL10171599 | 0.67 | GAA (0.43) | ALDH1A1GAATDP1EPHX2NPC1 | |
| SCHEMBL11693192 | 0.65 | GAA (0.46) | ALDH1A1GAATDP1EPHX2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100105693-A1 | Modulators of Muscarinic Receptors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100105693-A1 | Modulators of Muscarinic Receptors | CHRM3, CHRM5, CHRM2 | ALDH1A1 2741/4885GAA 4164/4885TDP1 4078/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.