Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | MMP8 | P22894 | 2/20 | 0.32 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | ACACB | O00763 | 2/20 | 0.31 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MERTK | Q12866 | 2/20 | 0.30 |
| ▸ | F2 | P00734 | 2/20 | 0.30 |
| ▸ | AXL | P30530 | 1/20 | 0.30 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.30 |
| ▸ | JAK3 | P52333 | 1/20 | 0.30 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11935506 | 1.00 | MAPK14 (0.37) | MAPK14PTGER4BTKMMP8MMP1 | |
| SCHEMBL17090539 | 0.81 | MAPK14 (0.34) | MAPK14PTGER4 | |
| SCHEMBL11935497 | 0.74 | PTGER4 (0.43) | MAPK14PTGER4BTKPDE4APDE4B | |
| SCHEMBL13439240 | 0.74 | PTGER4 (0.43) | MAPK14PTGER4BTKPDE4APDE4B | |
| SCHEMBL13439159 | 0.73 | MAPK14 (0.44) | MAPK14PTGER4PDE4APDE4BPDE4C | |
| SCHEMBL11935421 | 0.73 | MAPK14 (0.44) | MAPK14PTGER4PDE4APDE4BPDE4C | |
| SCHEMBL11935512 | 0.72 | MAPK14 (0.54) | MAPK14PTGER4PDE4APDE4BPDE4C | |
| SCHEMBL11935438 | 0.70 | SMYD3 (0.48) | MAPK14PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL13439170 | 0.70 | SMYD3 (0.48) | MAPK14PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL19224096 | 0.69 | TAS1R3 (0.44) | MMP8MMP1MMP2PKMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9150507-B2 | Amine derivative having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2015-10-06 | — | — | US | disclosed |
| US-9150507-B2 | Amine derivative having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2015-10-06 | — | — | US | disclosed |
| US-20100063027-A1 | Amine Derivative Having NPY Y5 Receptor Antagonistic Activity | SHIONOGI & CO., LTD. (JP) | 2010-03-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100063027-A1 | Amine Derivative Having NPY Y5 Receptor Antagonistic Activity | NPY5R, NPY1R, NPY2R | MAPK14 1624/4885PTGER4 935/4885BTK 1188/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.