Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1B | Q01064 | 6/20 | 0.43 |
| ▸ | PDE1C | Q14123 | 6/20 | 0.43 |
| ▸ | PDE1A | P54750 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2019618 | 0.87 | PDE1B (0.43) | PDE1BPDE1CPDE1AMAPTTHRB | |
| SCHEMBL1986657 | 0.84 | SMN1; SMN2 (0.46) | MAPTTHRBALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL15580732 | 0.79 | KDM4E (0.44) | ALDH1A1SMN1; SMN2HSD17B10KDM4ERXFP1 | |
| SCHEMBL3330739 | 0.75 | KDM4E (0.45) | THRBALDH1A1SMN1; SMN2HSD17B10KDM4E | |
| SCHEMBL14234457 | 0.72 | ALDH1A1 (0.46) | MAPTALDH1A1TSHRSMN1; SMN2KDM4E | |
| SCHEMBL16422358 | 0.72 | DCTPP1 (0.52) | PDE1BPDE1CPDE1AMAPTALDH1A1 | |
| SCHEMBL14234087 | 0.72 | ALDH1A1 (0.38) | MAPTALDH1A1TSHRKDM4ERXFP1 | |
| SCHEMBL3325418 | 0.72 | ALDH1A1 (0.50) | MAPTTHRBALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL21804847 | 0.71 | CNR2 (0.44) | PDE1BPDE1CPDE1AALDH1A1USP2 | |
| SCHEMBL31532042 | 0.71 | PDE1B (0.43) | PDE1BPDE1CPDE1AMAPTTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120309775-A1 | 4-METHYLPYRIDOPYRIMIDINONE COMPOUNDS | PFIZER INC (US) | 2012-12-06 | — | — | US | disclosed |
| US-7696213-B2 | 4-methylpyridopyrimidinone compounds | PFIZER INC (US) | 2010-04-13 | — | — | US | disclosed |
| US-20080090801-A1 | 4-METHYLPYRIDOPYRIMIDINONE COMPOUNDS | PFIZER INC. | 2008-04-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080090801-A1 | 4-METHYLPYRIDOPYRIMIDINONE COMPOUNDS | PI4KA, PI4KB, PIK3CA | PDE1B 1196/4885PDE1C 1273/4885PDE1A 1035/4885 |
| US-20120309775-A1 | 4-METHYLPYRIDOPYRIMIDINONE COMPOUNDS | PI4KA, PI4KB, PIK3CA | PDE1B 1196/4885PDE1C 1273/4885PDE1A 1035/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.