Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.40 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 6/20 | 0.33 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PDE5A | O76074 | 1/20 | 0.32 |
| ▸ | PDE1A | P54750 | 1/20 | 0.32 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7534860 | 0.88 | PGR (0.42) | PGRPARP10PARP11BACE1 | |
| SCHEMBL7555003 | 0.88 | PARP10 (0.40) | PGRPARP10PARP11BACE1 | |
| SCHEMBL7569767 | 0.86 | BACE1 (0.45) | PGRBACE1MEN1KMT2A | |
| SCHEMBL8197840 | 0.85 | BACE1 (0.43) | PARP10PARP11HTTBACE1MEN1 | |
| SCHEMBL7541624 | 0.85 | BACE1 (0.43) | PARP10PARP11HTTBACE1MEN1 | |
| SCHEMBL7541254 | 0.84 | CYP11B1 (0.48) | BACE1PDE5APDE1APDE1BPDE4D | |
| SCHEMBL7542913 | 0.82 | PARP10 (0.38) | PGRPARP10PARP11BACE1PDE5A | |
| SCHEMBL7535531 | 0.82 | PGR (0.42) | PGRPARP10PARP11BACE1PDE5A | |
| SCHEMBL17715727 | 0.82 | ALDH1A1 (0.38) | ALDH1A1HTTMAPTLMNAKDM4E | |
| SCHEMBL12498789 | 0.81 | PDE7A (0.34) | PGRBACE1PDE5APDE1APDE1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7700603-B2 | Heterocyclic aspartyl protease inhibitors | SCHERING CORPORATION (US) | 2010-04-20 | — | — | US | disclosed |
| EP-1838304-B1 | HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS | SCHERING CORP (US) | 2009-08-19 | — | — | EP | disclosed |