Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 3/20 | 0.74 |
| ▸ | MMP9 | P14780 | 3/20 | 0.74 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.74 |
| ▸ | MMP8 | P22894 | 2/20 | 0.74 |
| ▸ | GSK3B | P49841 | 3/20 | 0.72 |
| ▸ | BACE1 | P56817 | 3/20 | 0.72 |
| ▸ | MMP13 | P45452 | 2/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.65 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.65 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.65 |
| ▸ | STAT3 | P40763 | 2/20 | 0.65 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.65 |
| ▸ | RELA | Q04206 | 2/20 | 0.65 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.65 |
| ▸ | GLO1 | Q04760 | 2/20 | 0.64 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.64 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.64 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11928819 | 1.00 | MMP2 (0.74) | MMP2MMP9NFKB1MMP8GSK3B | |
| SCHEMBL4544307 | 1.00 | MMP2 (0.74) | MMP2MMP9NFKB1MMP8GSK3B | |
| SCHEMBL13358175 | 0.94 | GSK3B (0.71) | MMP2MMP9NFKB1MMP8GSK3B | |
| SCHEMBL16884580 | 0.94 | GSK3B (0.71) | MMP2MMP9NFKB1MMP8GSK3B | |
| SCHEMBL12291341 | 0.92 | GSK3B (0.65) | MMP2MMP9NFKB1MMP8GSK3B | |
| SCHEMBL13324431 | 0.91 | NFKB1 (0.83) | MMP2MMP9NFKB1MMP8GSK3B | |
| SCHEMBL6727006 | 0.90 | GSK3B (0.87) | MMP9NFKB1GSK3BBACE1MMP13 | |
| SCHEMBL3433171 | 0.90 | GSK3B (0.87) | MMP9NFKB1GSK3BBACE1MMP13 | |
| SCHEMBL242412 | 0.90 | GSK3B (0.87) | MMP9NFKB1GSK3BBACE1MMP13 | |
| SCHEMBL3680675 | 0.90 | GSK3B (0.87) | MMP9NFKB1GSK3BBACE1MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7682636-B2 | Curcuminoid compositions exhibiting synergistic inhibition of the expression and/or activity of cyclooxygenase-2 | METAPROTEOMICS, LLC (US) | 2010-03-23 | — | — | US | disclosed |
| US-20070141183-A1 | Curcuminoid compositions exhibiting synergistic inhibition of the expression and/or activity of cyclooxygenase-2 | METAPROTEOMICS, LLC (CA) | 2007-06-21 | — | — | US | disclosed |