Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 19/20 | 0.63 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.63 |
| ▸ | PARP4 | Q9UKK3 | 2/20 | 0.63 |
| ▸ | CA1 | P00915 | 1/20 | 0.63 |
| ▸ | CA2 | P00918 | 1/20 | 0.63 |
| ▸ | PARP1 | P09874 | 1/20 | 0.63 |
| ▸ | PARP15 | Q460N3 | 4/20 | 0.61 |
| ▸ | PARP14 | Q460N5 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | PARP16 | Q8N5Y8 | 1/20 | 0.61 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.61 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.53 |
| ▸ | TNKS | O95271 | 1/20 | 0.47 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9243495 | 0.83 | CA1 (0.59) | PARP10CA1CA2PARP15ALDH1A1 | |
| SCHEMBL9633891 | 0.83 | PARP10 (0.61) | PARP10PARP2PARP4CA1CA2 | |
| Terephthalamide SCHEMBL28194749 | 0.81 | PARP10 (0.58) | PARP10PARP2PARP4CA1CA2 | |
| SCHEMBL28554610 | 0.81 | PARP10 (0.59) | PARP10PARP2PARP4CA1CA2 | |
| SCHEMBL201761 | 0.77 | PARP10 (1.00) | PARP10PARP2PARP4CA1CA2 | |
| SCHEMBL3137816 | 0.77 | PARP10 (1.00) | PARP10PARP2PARP4CA1CA2 | |
| Hydrochloric Acid SCHEMBL408766 | 0.76 | PARP10 (0.95) | PARP10PARP2PARP4CA1CA2 | |
| Hydrochloric Acid SCHEMBL4376056 | 0.76 | PARP10 (0.95) | PARP10PARP2PARP4CA1CA2 | |
| Terephthalamide SCHEMBL23774 | 0.75 | PARP1 (0.71) | PARP10PARP2PARP4CA1CA2 | |
| SCHEMBL8747591 | 0.75 | CA1 (0.59) | CA1CA2ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8063093-B2 | Derivatives of 5-(halo)alkanoyl-6-hydroxy- benozofuran, benzothiophene, or indole; autoimmune diseases; systemic lupus erythematosis, rheumatoid arthritis, multiple sclerosis and psoriasis, transplant rejection; antiproliferative, anticarcinogenic, antidiabetic, antiinflammatory and antiulcer agents | HARVEY ANDREW J (AU) | 2011-11-22 | — | — | US | claimed |
| US-20080221194-A1 | Novel Potassium channel Blockers and Uses Thereof | HARVEY ANDREW J | 2008-09-11 | — | — | US | claimed |
| WO-2006096911-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS AND USES THEREOF | HARVEY ANDREW J (AU) | 2006-09-21 | — | — | WO | claimed |
| US-8063093-B2 | Derivatives of 5-(halo)alkanoyl-6-hydroxy- benozofuran, benzothiophene, or indole; autoimmune diseases; systemic lupus erythematosis, rheumatoid arthritis, multiple sclerosis and psoriasis, transplant rejection; antiproliferative, anticarcinogenic, antidiabetic, antiinflammatory and antiulcer agents | HARVEY ANDREW J (AU) | 2011-11-22 | — | — | US | disclosed |
| US-20080221194-A1 | Novel Potassium channel Blockers and Uses Thereof | HARVEY ANDREW J | 2008-09-11 | — | — | US | disclosed |
| US-4604481-A | Compounds for treatment or prophylaxis of cardiac disorders | AMERICAN HOSPITAL SUPPLY CORPORATION (US) | 1986-08-05 | — | — | US | disclosed |
| US-4405642-A | BETA-BLOCKING AROMATIC ESTER COMPOUND | AMERICAN HOSPITAL SUPPLY CORPORATION (US) | 1983-09-20 | — | — | US | disclosed |
| EP-0065964-A4 | METHOD FOR TREATMENT OR PROPHYLAXIS OF CARDIAC DISORDERS. | AMERICAN HOSPITAL SUPPLY CORP (US) | 1983-04-06 | — | — | EP | disclosed |
| EP-0065964-A1 | METHOD FOR TREATMENT OR PROPHYLAXIS OF CARDIAC DISORDERS. | AMERICAN HOSPITAL SUPPLY CORP (US) | 1982-12-08 | — | — | EP | disclosed |
| WO-1982001868-A1 | METHOD FOR TREATMENT OR PROPHYLAXIS OF CARDIAC DISORDERS | AMERICAN HOSPITAL SUPPLY CORP (US) | 1982-06-10 | — | — | WO | disclosed |
| EP-0053436-A1 | Method for treatment or prophylaxis of cardiac disorders | AMERICAN HOSPITAL SUPPLY CORPORATION (US) | 1982-06-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080221194-A1 | Novel Potassium channel Blockers and Uses Thereof | KCNAB1, KCNB1, KCNMB1 | PARP10 2309/4885PARP2 4028/4885PARP4 3260/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.