Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 18/20 | 0.61 |
| ▸ | PARP15 | Q460N3 | 5/20 | 0.61 |
| ▸ | PARP4 | Q9UKK3 | 2/20 | 0.61 |
| ▸ | PARP14 | Q460N5 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | PARP16 | Q8N5Y8 | 1/20 | 0.61 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.61 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.58 |
| ▸ | PARP2 | Q9UGN5 | 4/20 | 0.57 |
| ▸ | CA1 | P00915 | 1/20 | 0.57 |
| ▸ | CA2 | P00918 | 1/20 | 0.57 |
| ▸ | PARP1 | P09874 | 1/20 | 0.57 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.49 |
| ▸ | TNKS | O95271 | 1/20 | 0.47 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1344670 | 0.83 | PARP10 (0.63) | PARP10PARP15PARP4PARP14ALDH1A1 | |
| SCHEMBL10077968 | 0.81 | HTT (0.41) | PARP10PARP15PARP4PARP14ALDH1A1 | |
| SCHEMBL28554610 | 0.81 | PARP10 (0.59) | PARP10PARP15PARP4PARP14ALDH1A1 | |
| SCHEMBL6054668 | 0.80 | CA1 (0.56) | PARP10PARP15ALDH1A1KMT2ACA1 | |
| SCHEMBL25512146 | 0.79 | CA1 (0.39) | PARP10PARP15PARP4PARP14ALDH1A1 | |
| SCHEMBL4630373 | 0.79 | PARP10 (0.62) | PARP10PARP15PARP4PARP14ALDH1A1 | |
| SCHEMBL11306924 | 0.78 | MAPT (0.61) | ALDH1A1KMT2A | |
| SCHEMBL6454577 | 0.78 | ALDH1A1 (0.38) | ALDH1A1CA1CA2 | |
| SCHEMBL14405879 | 0.77 | HSD17B10 (0.53) | PARP10ALDH1A1KMT2A | |
| SCHEMBL14390120 | 0.77 | HSD17B10 (0.53) | PARP10ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0276124-B1 | PROSTAGLANDIN DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE | Sankyo Company Limited (JP) | 1992-05-20 | — | — | EP | disclosed |
| US-4981872-A | ANTIULCER | SANKYO COMPANY LIMITED (JP) | 1991-01-01 | — | — | US | disclosed |
| US-4933355-A | ALDOSE REDUCTASE INHIBITORS | SANKYO COMPANY LIMITED (JP) | 1990-06-12 | — | — | US | disclosed |
| EP-0337819-A1 | Thiazole derivatives, their preparation and their use in the treatment of diabetes complications | Sankyo Company Limited (JP) | 1989-10-18 | — | — | EP | disclosed |
| EP-0276124-A2 | Prostaglandin derivatives, their preparation and their therapeutic use | Sankyo Company Limited (JP) | 1988-07-27 | — | — | EP | disclosed |