Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.41 |
| ▸ | TNF | P01375 | 2/20 | 0.41 |
| ▸ | GAPDH | P04406 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | BMP2 | P12643 | 1/20 | 0.38 |
| ▸ | VEGFA | P15692 | 1/20 | 0.38 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.38 |
| ▸ | SHH | Q15465 | 1/20 | 0.38 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13786400 | 0.97 | LMNA (0.52) | LMNAKMT2AMAPK1CYP3A4MAPT | |
| SCHEMBL23763421 | 0.95 | LMNA (0.48) | LMNAKMT2AMAPK1CYP3A4MAPT | |
| SCHEMBL14878521 | 0.92 | LMNA (0.50) | LMNAKMT2AMAPK1CYP3A4MAPT | |
| SCHEMBL13447797 | 0.92 | LMNA (0.50) | LMNAKMT2AMAPK1CYP3A4MAPT | |
| SCHEMBL15592313 | 0.92 | LMNA (0.50) | LMNAKMT2AMAPK1CYP3A4MAPT | |
| SCHEMBL24997212 | 0.92 | LMNA (0.50) | LMNAKMT2AMAPK1CYP3A4MAPT | |
| SCHEMBL12248448 | 0.92 | LMNA (0.50) | LMNAKMT2AMAPK1CYP3A4MAPT | |
| SCHEMBL23394602 | 0.92 | LMNA (0.50) | LMNAKMT2AMAPK1CYP3A4MAPT | |
| SCHEMBL13117380 | 0.92 | LMNA (0.50) | LMNAKMT2AMAPK1CYP3A4MAPT | |
| SCHEMBL17850335 | 0.92 | LMNA (0.50) | LMNAKMT2AMAPK1CYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3034510-A1 | OLIGONUCLEOTIDES COMPRISING A C5-MODIFIED PYRIMIDINE | Alnylam Pharmaceuticals Inc. (US) | 2016-06-22 | — | — | EP | disclosed |
| US-7674778-B2 | Oligonucleotides comprising a conjugate group linked through a C5-modified pyrimidine | ALNYLAM PHARMACEUTICALS (US) | 2010-03-09 | — | — | US | disclosed |