Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.41 |
| ▸ | LGALS8 | O00214 | 1/20 | 0.39 |
| ▸ | LGALS3 | P17931 | 1/20 | 0.39 |
| ▸ | LGALS4 | P56470 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GAPDH | P04406 | 1/20 | 0.38 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.38 |
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14878521 | 1.00 | LMNA (0.50) | LMNAKMT2ACYP2C9CYP3A4MAPT | |
| SCHEMBL12248478 | 0.93 | LMNA (0.50) | LMNAKMT2ACYP2C9CYP3A4MAPT | |
| SCHEMBL19786845 | 0.92 | LMNA (0.53) | LMNAKMT2ACYP2C9CYP3A4MAPT | |
| SCHEMBL13447791 | 0.92 | LMNA (0.51) | LMNAKMT2ACYP2C9CYP3A4MAPT | |
| SCHEMBL13367679 | 0.92 | MAPK1 (0.49) | LMNAKMT2ACYP2C9CYP3A4MAPT | |
| SCHEMBL13117380 | 0.91 | LMNA (0.50) | LMNAKMT2ACYP2C9CYP3A4MAPT | |
| SCHEMBL15592313 | 0.91 | LMNA (0.50) | LMNAKMT2ACYP2C9CYP3A4MAPT | |
| SCHEMBL17850335 | 0.91 | LMNA (0.50) | LMNAKMT2ACYP2C9CYP3A4MAPT | |
| SCHEMBL24997212 | 0.91 | LMNA (0.50) | LMNAKMT2ACYP2C9CYP3A4MAPT | |
| SCHEMBL12248448 | 0.91 | LMNA (0.50) | LMNAKMT2ACYP2C9CYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11015194-B2 | iRNA agents with biocleavable tethers | ALNYLAM PHARMACEUTICALS, INC. (US) | 2021-05-25 | — | — | US | disclosed |