Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 11/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 5/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2805304 | 0.91 | REN (0.44) | RENMTNR1AMTNR1BNR1H4 | |
| SCHEMBL18509018 | 0.84 | REN (0.43) | RENNR1H4 | |
| SCHEMBL18509013 | 0.81 | REN (0.41) | RENNR1H4 | |
| SCHEMBL13132250 | 0.80 | REN (0.43) | RENNR1H4 | |
| SCHEMBL13132246 | 0.80 | MTNR1A (0.44) | RENMTNR1AMTNR1BNR1H4 | |
| SCHEMBL13132485 | 0.73 | REN (0.47) | RENNR1H4 | |
| SCHEMBL2814031 | 0.73 | REN (0.64) | RENMTNR1AMTNR1BNR1H4 | |
| SCHEMBL2811860 | 0.72 | REN (0.45) | RENNR1H4 | |
| SCHEMBL1518385 | 0.69 | REN (0.47) | REN | |
| SCHEMBL2807712 | 0.69 | REN (0.42) | RENNR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2168952-A1 | MORPHOLINE DERIVATIVE | Mitsubishi Tanabe Pharma Corporation (JP) | 2010-03-31 | — | — | EP | disclosed |