Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.52 |
| ▸ | NOS2 | P35228 | 1/20 | 0.52 |
| ▸ | PROKR1 | Q8TCW9 | 2/20 | 0.42 |
| ▸ | POLQ | O75417 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | IDH2 | P48735 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19192034 | 0.86 | CYP1A2 (0.41) | NOS3NOS2PROKR1POLQMAPK1 | |
| SCHEMBL3216629 | 0.85 | NOS3 (0.53) | NOS3NOS2POLQMAPK1CYP1A2 | |
| SCHEMBL8979102 | 0.82 | NOS3 (0.46) | NOS3NOS2POLQMAPK1ADRB1 | |
| SCHEMBL30695508 | 0.82 | NOS3 (0.46) | NOS3NOS2PROKR1POLQMAPK1 | |
| SCHEMBL803102 | 0.82 | CYP1A2 (0.40) | NOS3NOS2PROKR1MAPK1CYP1A2 | |
| SCHEMBL14547839 | 0.80 | NOS3 (0.44) | NOS3NOS2PROKR1POLQMAPK1 | |
| SCHEMBL27799117 | 0.79 | NOS3 (0.47) | NOS3NOS2POLQMAPK1ADRB1 | |
| SCHEMBL13570887 | 0.79 | POLQ (0.45) | NOS3NOS2PROKR1POLQHSD17B10 | |
| SCHEMBL26988024 | 0.78 | PROKR1 (0.35) | NOS3NOS2PROKR1POLQMAPK1 | |
| SCHEMBL23839470 | 0.77 | AR (0.48) | NOS3NOS2POLQMAPK1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2228366-B1 | Method for producing 2-amino-4-(halogenalkyl)pyridine derivatives by means of cyclization of suitable nitrile precursors with nitrogen combinations | ARCHIMICA GMBH (DE) | 2011-12-28 | — | — | EP | disclosed |
| EP-2228366-B1 | Method for producing 2-amino-4-(halogenalkyl)pyridine derivatives by means of cyclization of suitable nitrile precursors with nitrogen combinations | ARCHIMICA GMBH (DE) | 2011-12-28 | — | — | EP | disclosed |
| US-8063226-B2 | Process for preparing 2-amino-4-(haloalkyl) pyridine derivatives by cyclizing suitable nitrile precursors with nitrogen compounds | ARCHIMICA GMBH (DE) | 2011-11-22 | — | — | US | disclosed |
| US-8063226-B2 | Process for preparing 2-amino-4-(haloalkyl) pyridine derivatives by cyclizing suitable nitrile precursors with nitrogen compounds | ARCHIMICA GMBH (DE) | 2011-11-22 | — | — | US | disclosed |
| US-20100234607-A1 | Process for preparing 2-amino-4- (haloalkyl) pyridine derivatives by cyclizing suitable nitrile precursors with nitrogen compounds | EUTICALS GMBH (DE) | 2010-09-16 | — | — | US | disclosed |
| US-20100234607-A1 | Process for preparing 2-amino-4- (haloalkyl) pyridine derivatives by cyclizing suitable nitrile precursors with nitrogen compounds | EUTICALS GMBH (DE) | 2010-09-16 | — | — | US | disclosed |
| EP-2228366-A1 | Method for producing 2-amino-4-(halogenalkyl)pyridine derivatives by means of cyclization of suitable nitrile precursors with nitrogen combinations | Archimica GmbH (DE) | 2010-09-15 | — | — | EP | disclosed |
| EP-2228366-A1 | Method for producing 2-amino-4-(halogenalkyl)pyridine derivatives by means of cyclization of suitable nitrile precursors with nitrogen combinations | Archimica GmbH (DE) | 2010-09-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100234607-A1 | Process for preparing 2-amino-4- (haloalkyl) pyridine derivatives by cyclizing suitable nitrile precursors with nitrogen compounds | NISCH, NIT2, ASNS | NOS3 138/4885NOS2 16/4885PROKR1 2878/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.