Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT1 | P36639 | 6/20 | 0.51 |
| ▸ | JAK1 | P23458 | 3/20 | 0.48 |
| ▸ | EGLN2 | Q96KS0 | 2/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | LTK | P29376 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
| ▸ | PRKX | P51817 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 4/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2254013 | 0.81 | NUDT1 (0.47) | NUDT1JAK1EGLN2JAK3BRD4 | |
| SCHEMBL3300546 | 0.76 | NUDT1 (0.57) | NUDT1JAK1EGLN2JAK3KDM4E | |
| SCHEMBL24656050 | 0.75 | NUDT1 (0.59) | NUDT1JAK1EGLN2JAK3KDM4E | |
| SCHEMBL3098201 | 0.73 | NUDT1 (0.62) | NUDT1JAK1EGLN2JAK3KDM4E | |
| SCHEMBL13465776 | 0.73 | NUDT1 (0.58) | NUDT1JAK1EGLN2JAK3KDM4E | |
| SCHEMBL27038245 | 0.72 | NUDT1 (0.56) | NUDT1JAK1EGLN2JAK3KDM4E | |
| SCHEMBL2773330 | 0.72 | NUDT1 (0.57) | NUDT1JAK1EGLN2JAK3KDM4E | |
| SCHEMBL30927826 | 0.72 | NUDT1 (0.56) | NUDT1JAK1EGLN2JAK3KDM4E | |
| SCHEMBL45713 | 0.72 | NUDT1 (0.56) | NUDT1JAK1EGLN2JAK3KDM4E | |
| SCHEMBL3596030 | 0.71 | NUDT1 (0.51) | NUDT1JAK1EGLN2JAK3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160024089-A1 | TRIAZOLOPYRIDINE JAK INHIBITOR COMPOUNDS AND METHODS | GENENTECH, INC. (US) | 2016-01-28 | — | — | US | disclosed |
| US-20140378449-A1 | TRIAZOLOPYRIDINE JAK INHIBITOR COMPOUNDS AND METHODS | GENENTECH, INC. (US) | 2014-12-25 | — | — | US | disclosed |
| US-8889673-B2 | Triazolopyridine JAK inhibitor compounds and methods | GENENTECH, INC. (US) | 2014-11-18 | — | — | US | disclosed |
| US-20120264747-A1 | TRIAZOLOPYRIDINE JAK INHIBITOR COMPOUNDS AND METHODS | ZHU BING-YAN (US) | 2012-10-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140378449-A1 | TRIAZOLOPYRIDINE JAK INHIBITOR COMPOUNDS AND METHODS | JAK2, JAK1, JAK3 | NUDT1 3080/4885JAK1 2/4885EGLN2 3771/4885 |
| US-20160024089-A1 | TRIAZOLOPYRIDINE JAK INHIBITOR COMPOUNDS AND METHODS | JAK2, JAK1, JAK3 | NUDT1 3080/4885JAK1 2/4885EGLN2 3771/4885 |
| US-20120264747-A1 | TRIAZOLOPYRIDINE JAK INHIBITOR COMPOUNDS AND METHODS | JAK2, JAK1, JAK3 | NUDT1 3080/4885JAK1 2/4885EGLN2 3771/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.