Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13449709 | 0.92 | ALDH1A1 (0.51) | ALDH1A1KDM4EHSD17B10SMN1; SMN2HPGD | |
| SCHEMBL12877352 | 0.91 | SMN1; SMN2 (0.49) | ALDH1A1KDM4EHSD17B10SMN1; SMN2HPGD | |
| SCHEMBL13449707 | 0.91 | ALDH1A1 (0.49) | ALDH1A1KDM4EHSD17B10SMN1; SMN2HPGD | |
| SCHEMBL13449710 | 0.90 | ALDH1A1 (0.51) | ALDH1A1KDM4EHSD17B10SMN1; SMN2HPGD | |
| SCHEMBL13449702 | 0.90 | ALDH1A1 (0.53) | ALDH1A1KDM4EHSD17B10SMN1; SMN2HPGD | |
| SCHEMBL13449708 | 0.89 | ALDH1A1 (0.48) | ALDH1A1KDM4EHSD17B10SMN1; SMN2HPGD | |
| Lisavanbulin SCHEMBL1160313 | 0.89 | ALDH1A1 (0.48) | ALDH1A1KDM4EHSD17B10SMN1; SMN2HPGD | |
| Lisavanbulin SCHEMBL18466601 | 0.89 | ALDH1A1 (0.48) | ALDH1A1KDM4EHSD17B10SMN1; SMN2HPGD | |
| Lisavanbulin SCHEMBL29374059 | 0.89 | ALDH1A1 (0.48) | ALDH1A1KDM4EHSD17B10SMN1; SMN2HPGD | |
| SCHEMBL13449706 | 0.89 | ALDH1A1 (0.45) | ALDH1A1KDM4EHSD17B10SMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2459553-B1 | FURAZANOBENZIMIDAZOLES AS PRODRUGS TO TREAT NEOPLASTIC OR AUTOIMMUNE DISEASES | BASILEA PHARMACEUTICA AG (CH) | 2014-10-01 | — | — | EP | disclosed |
| US-8802858-B2 | Furazanobenzimidazoles as prodrugs to treat neoplastic or autoimmune diseases | BASILEA PHARMACEUTICA AG (CH) | 2014-08-12 | — | — | US | disclosed |
| US-8802858-B2 | Furazanobenzimidazoles as prodrugs to treat neoplastic or autoimmune diseases | BASILEA PHARMACEUTICA AG (CH) | 2014-08-12 | — | — | US | disclosed |
| US-20120264792-A1 | FURAZANOBENZIMIDAZOLES AS PRODRUGS TO TREAT NEOPLASTIC OR AUTOIMMUNE DISEASES | BASILEA PHARMACEUTICA AG | 2012-10-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120264792-A1 | FURAZANOBENZIMIDAZOLES AS PRODRUGS TO TREAT NEOPLASTIC OR AUTOIMMUNE DISEASES | SSB, VHL, AHR | ALDH1A1 838/4885KDM4E 926/4885HSD17B10 701/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.